2.4.1.277: 10-deoxymethynolide desosaminyltransferase
This is an abbreviated version!
For detailed information about 10-deoxymethynolide desosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.277
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2.4.1.277
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venezuelae
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pikromycin
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polyketide
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deoxysugars
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aglycone
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macrolactone
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d-desosamine
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methymycin
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erythromycin
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tylosin
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synthases
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auxiliary
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tylactone
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interspecies
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saccharopolyspora
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medicine
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neomethymycin
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unnatural
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l-rhamnose
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bioconversion
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fradiae
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cassettes
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erythraea
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erythromycin-susceptible
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faecium
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enterococcus
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narbomycin
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aureus
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16-membered
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glycosyltransferases
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synthesis
- 2.4.1.277
- venezuelae
- pikromycin
- polyketide
-
deoxysugars
-
aglycone
-
macrolactone
-
d-desosamine
- methymycin
- erythromycin
- tylosin
- synthases
-
auxiliary
- tylactone
-
interspecies
-
saccharopolyspora
- medicine
- neomethymycin
-
unnatural
- l-rhamnose
-
bioconversion
- fradiae
- cassettes
- erythraea
-
erythromycin-susceptible
- faecium
-
enterococcus
- narbomycin
- aureus
-
16-membered
- glycosyltransferases
- synthesis
Reaction
Synonyms
DesVII, DesVII/DesVIII, glycosyltransferase DesVII, macrolide glycosyltransferase DesVII
ECTree
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General Information
General Information on EC 2.4.1.277 - 10-deoxymethynolide desosaminyltransferase
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physiological function
the enzyme is involved in biosynthesis of macrolide antibiotics
physiological function
coexpression of glycosyltransferase DesVII and its auxiliary partner DesVIII in a Saccharopolyspora erythraea EryBV deletion mutant leads to an increased erythromycin A yield by 15% in comparison to Saccharopolyspora erythraea wild-type. DesVII/DesVIII replaced EryCIII to upload D-desosamine to C5 position of 3-O-mycarosyl erythronolide B and also in vivo attache L-mycarose, not D-desosamine to C3 position of erythronolide B with a higher activity than EryBV. Expression of DesVII in EryCIII and EryBV-CIII mutant strains partially restores the erythromycin A production, however, no erythromycin A is detected while DesVII is expressed in the EryBV mutant strain