2.4.1.227: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol

beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetylmuramoylpentapeptide pyrophospholipid, gene murG enzyme, gene murG proteins, HyMurG, Lipid I acetylglucosaminyltransferase, MsmegMurG, MurG, MurG glycosyltransferase, MurG transferase, peptidoglycan glycosyltransferase, proteins, gene murG, translocase II, UDP-acetylglucosamine-acetylmuramoylpentapeptide pyrophospholipid acetylglucosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.227 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase

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Results	in table
9	Activating Compound
40181	AA Sequence
8	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Crystallization (Commentary)
18	General Information
1	General Stability
17	IC50 Value
71	Inhibitors
44	KM Value [mM]
20	Localization
2	Metals/Ions
8	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
33	Organism
9	Pathway
4	PDB ID
4	pH Optimum
1	pH Range
20	Protein Variants
9	Purification (Commentary)
2	Reaction
4	Reaction Type
32	Reference
23	Specific Activity [micromol/min/mg]
3	Storage Stability
45	Substrates and Products (Substrate)
6	Subunits
40	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
18	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.4.1.227 - undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase

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0.0014

(5E)-5-[(4-tert-butylphenyl)methylidene]-3-[(4-methylpiperidin-1-yl)methyl]-2-sulfanylidene-1,3-thiazolidin-4-one

Escherichia coli

pH 7.9, temperature not specified in the publication

758938

0.0064

(5E)-5-[(5-bromofuran-2-yl)methylidene]-1-(4-chlorophenyl)-1,3-diazinane-2,4,6-trione

Escherichia coli

pH 7.9, temperature not specified in the publication

758938

0.0035

2-[(5Z)-5-(1-benzyl-5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethane-1-sulfonic acid

Escherichia coli

pH 7.9, temperature not specified in the publication

758938

0.0054

3-[[(3E)-3-[[5-(4-bromophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]methyl]benzoic acid

Escherichia coli

pH 7.9, temperature not specified in the publication

758938

0.0014

5-(3-[(E)-[1-(3-chlorophenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-2,5-dimethyl-1H-pyrrol-1-yl)benzene-1,3-dicarboxylic acid

Escherichia coli

pH 7.9, temperature not specified in the publication

758938

0.004

5-([3-[2-(4-tert-butylphenoxy)ethoxy]phenyl]methylidene)-2-sulfanylidene-1,3-diazinane-4,6-dione

Escherichia coli

pH 7.9, temperature not specified in the publication

758938

0.0087 - 0.0095

nikkomycin Z

2 entries

0.0508 - 0.055

Polyoxin D

2 entries

0.0035

PyDT-1

Mycolicibacterium smegmatis

pH 8.0, 37°C

758570

0.0224 - 0.0235

ramoplanin A2

2 entries

0.00096 - 0.0014

ristocetin A

2 entries

0.002

ToXa-1

Mycolicibacterium smegmatis

pH 8.0, 37°C

758570

0.0034

[(5E)-5-[(3-bromo-5-chloro-2-hydroxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

Escherichia coli

pH 7.9, temperature not specified in the publication

758938