Cloned (Comment) | Organism |
---|---|
the murG gene is cloned with an N-terminal His6 tag into a pET33b vector. The plasmid is transformed and expressed in Escherichia coli NiCo21(DE3) competent cells | Mycolicibacterium smegmatis |
the murG gene is cloned with an N-terminal His6 tag into a pET33b vector. The plasmid was transformed and expressed in Escherichia coli NiCo21(DE3) competent cells | Hydrogenivirga sp. 128-5-R1-1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nikkomycin Z | - |
Hydrogenivirga sp. 128-5-R1-1 | |
nikkomycin Z | - |
Mycolicibacterium smegmatis | |
Polyoxin D | - |
Hydrogenivirga sp. 128-5-R1-1 | |
Polyoxin D | - |
Mycolicibacterium smegmatis | |
PyDT-1 | - |
Mycolicibacterium smegmatis | |
ramoplanin A2 | - |
Hydrogenivirga sp. 128-5-R1-1 | |
ramoplanin A2 | - |
Mycolicibacterium smegmatis | |
ristocetin A | strong antimycobacterial MurG inhibitor | Hydrogenivirga sp. 128-5-R1-1 | |
ristocetin A | strong antimycobacterial MurG inhibitor | Mycolicibacterium smegmatis | |
ToXa-1 | - |
Mycolicibacterium smegmatis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hydrogenivirga sp. 128-5-R1-1 | A8US35 | - |
- |
Mycolicibacterium smegmatis | - |
- |
- |
Mycolicibacterium smegmatis ATCC 607 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycolicibacterium smegmatis |
- |
Hydrogenivirga sp. 128-5-R1-1 |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
fluorescence-based assay | Mycolicibacterium smegmatis |
additional information | - |
fluorescence-based assay | Hydrogenivirga sp. 128-5-R1-1 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + C55-lipid I-Nepsilon-C6-dansyl thiourea | - |
Mycolicibacterium smegmatis | UDP + C55-lipid II-Nepsilon-C6-dansyl thiourea | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + C55-lipid I-Nepsilon-C6-dansyl thiourea | - |
Hydrogenivirga sp. 128-5-R1-1 | UDP + C55-lipid II-Nepsilon-C6-dansyl thiourea | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + C55-lipid I-Nepsilon-C6-dansyl thiourea | - |
Mycolicibacterium smegmatis ATCC 607 | UDP + C55-lipid II-Nepsilon-C6-dansyl thiourea | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HyMurG | - |
Hydrogenivirga sp. 128-5-R1-1 |
MsmegMurG | - |
Mycolicibacterium smegmatis |
MurG | - |
Mycolicibacterium smegmatis |
MurG | - |
Hydrogenivirga sp. 128-5-R1-1 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00096 | - |
pH 8.0, 37°C | Hydrogenivirga sp. 128-5-R1-1 | ristocetin A | |
0.0014 | - |
pH 8.0, 37°C | Mycolicibacterium smegmatis | ristocetin A | |
0.002 | - |
pH 8.0, 37°C | Mycolicibacterium smegmatis | ToXa-1 | |
0.0035 | - |
pH 8.0, 37°C | Mycolicibacterium smegmatis | PyDT-1 | |
0.0087 | - |
pH 8.0, 37°C | Hydrogenivirga sp. 128-5-R1-1 | nikkomycin Z | |
0.0095 | - |
pH 8.0, 37°C | Mycolicibacterium smegmatis | nikkomycin Z | |
0.0224 | - |
pH 8.0, 37°C | Hydrogenivirga sp. 128-5-R1-1 | ramoplanin A2 | |
0.0235 | - |
pH 8.0, 37°C | Mycolicibacterium smegmatis | ramoplanin A2 | |
0.0508 | - |
pH 8.0, 37°C | Hydrogenivirga sp. 128-5-R1-1 | Polyoxin D | |
0.055 | - |
pH 8.0, 37°C | Mycolicibacterium smegmatis | Polyoxin D |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is an essential bacterial glycosyltransferase that catalyses the GlcNAc-transformation of lipid I to lipid II during peptidoglycan biosynthesis | Mycolicibacterium smegmatis |
metabolism | the enzyme is an essential bacterial glycosyltransferase that catalyses the GlcNAc-transformation of lipid I to lipid II during peptidoglycan biosynthesis | Hydrogenivirga sp. 128-5-R1-1 |