2.4.1.182: lipid-A-disaccharide synthase

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Word Map on EC 2.4.1.182

2.4.1.182

acyltransferase

raetz

clockwise

udp-glcnac

lipopolysaccharide

paralogue

lps

udp-2,3-diacylglucosamine

castellanii

cotranscribed

amoebae

micelle

pneumophila

bacteriol

acanthamoeba

glycerophospholipids

resin

udp-n-acetylglucosamine

synthesis

Reaction

a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine

Synonyms

lcsC, lcsC/lpxB1, Legionella cytotoxic suppressor C, lipid A disaccharide synthase, lipid A disaccharide synthetase, LpxB, More, pgsB, synthase, lipid A disaccharide

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.182 lipid-A-disaccharide synthase

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Results	in table
6	Activating Compound
26409	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
18	General Information
2	Inhibitors
3	KM Value [mM]
15	Localization
1	Metals/Ions
12	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
25	Organism
11	Pathway
4	PDB ID
7	pH Optimum
1	pH Range
21	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
23	Reference
7	Specific Activity [micromol/min/mg]
1	Storage Stability
36	Substrates and Products (Substrate)
11	Subunits
35	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.4.1.182 - lipid-A-disaccharide synthase

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UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyltransferase

Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria.