2.4.1.182: lipid-A-disaccharide synthase

This is an abbreviated version!
For detailed information about lipid-A-disaccharide synthase, go to the full flat file.

Reaction

Synonyms

lcsC, lcsC/lpxB1, Legionella cytotoxic suppressor C, lipid A disaccharide synthase, lipid A disaccharide synthetase, LpxB, More, pgsB, synthase, lipid A disaccharide

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.182 lipid-A-disaccharide synthase

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Results	in table
6	Activating Compound
26409	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
18	General Information
2	Inhibitors
3	KM Value [mM]
15	Localization
1	Metals/Ions
12	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
25	Organism
11	Pathway
4	PDB ID
7	pH Optimum
1	pH Range
21	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
23	Reference
7	Specific Activity [micromol/min/mg]
1	Storage Stability
36	Substrates and Products (Substrate)
11	Subunits
35	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]

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Reference on EC 2.4.1.182 - lipid-A-disaccharide synthase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

638252

Ray, B.L.; Painter, G.; Raetz, C.R.H.

The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli

J. Biol. Chem.

259

4852-4859

1984

Escherichia coli

6370995

brenda

638253

Crowell, D.N.; Reznikoff, W.S.; Raetz, C.R.H.

Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase

J. Bacteriol.

169

5727-5734

1987

Escherichia coli

2824445

brenda

638254

Crowell, D.N.; Anderson, M.S.; Raetz, C.R.H.

Molecular cloning of the genes for lipid A disaccharide synthase and UDP-N-acetylglucosamine acyltransferase in Escherichia coli

J. Bacteriol.

168

152-159

1986

Escherichia coli

3531165

brenda

638255

Radika, K.; Raetz, C.R.H.

Purification and properties of lipid A disaccharide synthase of Escherichia coli

J. Biol. Chem.

263

14859-14867

1988

Escherichia coli, Escherichia coli MC1061/pSR8

3049593

brenda

638256

Raetz, C.R.H.

Lipid A disaccharide synthase from Escherichia coli

Methods Enzymol.

209

455-466

1992

Escherichia coli, Escherichia coli MC1061/pSR8

1495426

brenda

638257

Vyplel, H.; Scholz, D.; Loibner, H.; Kern, M.; Bednarik, K.; Schaller, H.

Synthesis of fluorinated analogues of lipid A

Tetrahedron Lett.

33

1261-1264

1992

Escherichia coli

-

brenda

638258

Milla, M.E.; Raetz, C.R.H.

Association of lipid A disaccharide synthase with aerobic glycerol-3-phosphate dehydrogenase in extracts of Escherichia coli

Biochim. Biophys. Acta

1304

245-253

1996

Escherichia coli

8982270

brenda

638259

Price, N.P.J.; Kelly, T.M.; Raetz, C.R.H.; Carlson, R.W.

Biosynthesis of a structurally novel lipid A in Rhizobium leguminosarum: Identification and characterization of six metabolic steps leading from UDP-GlcNAc to 3-deoxy-D-manno-2-octulosonic acid2-lipid IVA

J. Bacteriol.

176

4646-4655

1994

Rhizobium leguminosarum

8045896

brenda

694027

Albers, U.; Tiaden, A.; Spirig, T.; Al Alam, D.; Goyert, S.M.; Gangloff, S.C.; Hilbi, H.

Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions

Microbiology

153

3817-3829

2007

Legionella pneumophila (Q5WSK6), Legionella pneumophila (Q5WWX7), Legionella pneumophila (Q5X5J5), Legionella pneumophila

17975091

brenda

702266

Metzger, L.E.; Raetz, C.R.

Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein

Biochemistry

48

11559-11571

2009

Escherichia coli, Haemophilus influenzae, Escherichia coli C41(DE3)

19883124

brenda

718879

Metzger, L.E.; Raetz, C.R.

An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis

Biochemistry

49

6715-6726

2010

Arabidopsis thaliana (F4IF99), Arabidopsis thaliana Col-0 (F4IF99)

20608695

brenda

737072

Emiola, A.; George, J.; Andrews, S.S.

A complete pathway model for lipid A biosynthesis in Escherichia coli

PLoS ONE

10

e0121216

2014

Escherichia coli (P10441)

25919634

brenda

758842

Zhou, P.; Zhao, J.

Structure, inhibition, and regulation of essential lipid A enzymes

Biochim. Biophys. Acta

1862

1424-1438

2017

Chlamydia trachomatis (O84416), Escherichia coli (P10441), Chlamydia trachomatis D/UW-3/Cx (O84416)

27940308

brenda

759836

Bohl, T.E.; Shi, K.; Lee, J.K.; Aihara, H.

Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli

Nat. Commun.

9

377

2018

Escherichia coli (P10441), Escherichia coli

29371662

brenda

Entries 1 - 20 of 14

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