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2.4.1.131: GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

This is an abbreviated version!
For detailed information about GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.131

Reaction

2 GDP-alpha-D-mannose +

alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
= 2 GDP +
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol

Synonyms

Alg11, Alg2 mannosyltransferase, At2G40190, galactomannan deficiency protein 3, GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, gmd3, guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase, hALG11, LEW3, mannosyltransferase, guanosine diphosphomannose-oligosaccharide-lipid, oligosaccharide-lipid mannosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.131 GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

Reference

topprint

Reference on EC 2.4.1.131 - GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schutzbach, J.S.; Springfield, J.D.; Jensen, J.W.
The biosynthesis of oligosaccharide-lipids. Formation of an alpha-1,2-mannosyl-mannose linkage
J. Biol. Chem.
255
4170-4175
1980
Oryctolagus cuniculus
Manually annotated by BRENDA team
Spencer, J.P.; Elbein, A.D.
Transfer of mannose from GDP-mannose to lipid-linked oligosaccharide by soluble mannosyl transferase
Proc. Natl. Acad. Sci. USA
77
2524-2527
1980
Sus scrofa
Manually annotated by BRENDA team
Jensen, J.W.; Springfield, J.D.; Schutzbach, J.S.
The biosynthesis of oligosaccharide-lipids. Isolation of an oligosaccharide-P-P-lipid acceptor
J. Biol. Chem.
255
11268-11272
1980
Oryctolagus cuniculus
Manually annotated by BRENDA team
Prakash, C.; Katial, A.; Kang, M.S.; Vijay, I.K.
Solubilization of mannosyltransferase activities for the biosynthesis of mammary glycoproteins. Elongation of tetrasaccharide-lipid to heptasaccharide-lipid by a solubilized enzyme preparation
Eur. J. Biochem.
139
87-93
1984
Bos taurus
Manually annotated by BRENDA team
Cipollo, J.F.; Trimble, R.B.
The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man-residues of Glc(3)Man(9)GlcNAc(2)-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus
Glycobiology
12
749-762
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Gao, X.D.; Nishikawa, A.; Dean, N.
Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum
Glycobiology
14
559-570
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Absmanner, B.; Schmeiser, V.; Kämpf, M.; Lehle, L.
Biochemical characterization, membrane association and identification of amino acids essential for the function of Alg11 from Saccharomyces cerevisiae, an alpha1,2-mannosyltransferase catalysing two sequential glycosylation steps in the formation of the lipid-linked core oligosaccharide
Biochem. J.
426
205-217
2010
Saccharomyces cerevisiae (P53954), Saccharomyces cerevisiae
Manually annotated by BRENDA team
O'Reilly, M.K.; Zhang, G.; Imperiali, B.
In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis
Biochemistry
45
9593-9603
2006
Saccharomyces cerevisiae (P53954), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Rind, N.; Schmeiser, V.; Thiel, C.; Absmanner, B.; Lübbehusen, J.; Hocks, J.; Apeshiotis, N.; Wilichowski, E.; Lehle, L.; Körner, C.
A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip
Hum. Mol. Genet.
19
1413-1424
2010
Homo sapiens (Q2TAA5), Homo sapiens
Manually annotated by BRENDA team
Cipollo, J.F.; Trimble, R.B.; Chi, J.H.; Yan, Q.; Dean, N.
The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum
J. Biol. Chem.
276
21828-21840
2001
Saccharomyces cerevisiae (P53954), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Zhang, M.; Henquet, M.; Chen, Z.; Zhang, H.; Zhang, Y.; Ren, X.; van der Krol, S.; Gonneau, M.; Bosch, D.; Gong, Z.
LEW3, encoding a putative alpha-1,2-mannosyltransferase (ALG11) in N-linked glycoprotein, plays vital roles in cell-wall biosynthesis and the abiotic stress response in Arabidopsis thaliana
Plant J.
60
983-999
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Umeda, K.; Yoko-o, T.; Nakayama, K.; Suzuki, T.; Jigami, Y.
Schizosaccharomyces pombe gmd3(+)/alg11(+) is a functional homologue of Saccharomyces cerevisiae ALG11 which is involved in N-linked oligosaccharide synthesis
Yeast
16
1261-1271
2000
Schizosaccharomyces pombe (O74878), Schizosaccharomyces pombe, Saccharomyces cerevisiae (P53954), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ramirez, A.S.; Boilevin, J.; Lin, C.W.; Ha Gan, B.; Janser, D.; Aebi, M.; Darbre, T.; Reymond, J.L.; Locher, K.P.
Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins
Glycobiology
27
726-733
2017
Saccharomyces cerevisiae (P53954), Saccharomyces cerevisiae ATCC 204508 (P53954)
Manually annotated by BRENDA team