2.4.1.131: GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
This is an abbreviated version!
For detailed information about GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.131
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2.4.1.131
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lipid-linked
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n-glycosylation
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n-linked
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glycosyltransferase
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dolichol-linked
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asparagine-linked
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man5glcnac2-pp-dolichol
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alpha1,2-linked
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single-subunit
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oligosaccharyltransferase
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man5glcnac2-pp-dol
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microcephaly
- 2.4.1.131
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lipid-linked
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n-glycosylation
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n-linked
- glycosyltransferase
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dolichol-linked
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asparagine-linked
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man5glcnac2-pp-dolichol
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alpha1,2-linked
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single-subunit
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oligosaccharyltransferase
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man5glcnac2-pp-dol
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microcephaly
Reaction
2 GDP-alpha-D-mannose + = 2 GDP +
Synonyms
Alg11, Alg2 mannosyltransferase, At2G40190, galactomannan deficiency protein 3, GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, gmd3, guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase, hALG11, LEW3, mannosyltransferase, guanosine diphosphomannose-oligosaccharide-lipid, oligosaccharide-lipid mannosyltransferase
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Substrates Products
Substrates Products on EC 2.4.1.131 - GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
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REACTION DIAGRAM
2 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
2 UDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
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?
2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
GDP-mannose + lipid-linked Manalpha(1-3)Manbeta-GlcNAcbeta-GlcNAc
GDP + lipid-linked Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta-GlcNAcbeta-GlcNAc
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reaction via penta- and hexasaccharide intermediates to a lipid-linked heptasaccharide, presumably multiple mannosyltransferases involved
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?
GDP-mannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
GDPmannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
2 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
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?
2 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
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?
2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
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?
2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
mannosyltransferase Alg11 carries out two consecutive alpha-1,2-mannosylation steps of the substrate Manalpha1,3-(Manalpha1,6)-Man-beta1,4-GlcNAc-beta1,4-GlcNAc-diphosphodolichol. Biosynthesis of asparagine-linked glycoproteins, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway
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?
2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
the biosynthesis of asparagine-linked glycans occurs in an evolutionarily conserved manner with the assembly of the unique lipid-linked oligosaccharide precursor Glc3Man9GlcNAc2-PPDo at the endoplasmic reticulum. The enzyme catalyzes the transfer of two alpha1,2-linked mannose residues from GDP-mannose to Man3GlcNAc2-PP-Dol and subsequently to Man4GlcNAc2-PP-Dol forming the Man5GlcNAc2-PP-Dol intermediate at the cytosolic side of the endoplasmic reticulum before flipping to the luminal side
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?
2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
mannosyltransferase Alg11 carries out two consecutive alpha-1,2-mannosylation steps of the substrate Manalpha1,3-(Manalpha1,6)-Man-beta1,4-GlcNAc-beta1,4-GlcNAc-diphosphodolichol
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?
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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acceptors can be mannose or Man-(GlcNAc)2 to (Man)5-(GlcNAc)2, lipid-linked tetrasaccharide Manalpha(1-3)Manbeta-GlcNAcbeta-GlcNAc, presumably multiple mannosyltransferases involved
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?
GDP-mannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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acceptor isolated from baby hamster kidney cells, i.e. BHK cells
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?
GDP-mannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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oligosaccharide-P-P-lipid: major oligosaccharide component is Man2GlcNAc2
penta-, hexa-, and heptasaccharide as oligosaccharide portion, formed by the stepwise addition of mannose to the growing oligosaccharide chain
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GDP-mannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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acceptor isolated from pig liver
presumably a heptasaccharide with a 1,6-linked branched glycosyl unit with 65% of the newly added mannosyl units in a terminal nonreducing position, structure may be Manalpha(1-2)Man-Man(Man(1-6))Man-GlcNAc-GlcNAc
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GDP-mannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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acceptor isolated from pig liver
penta-, hexa-, and heptasaccharide as oligosaccharide portion, formed by the stepwise addition of mannose to the growing oligosaccharide chain
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GDP-mannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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oligosaccharide portion: a mixture of trisaccharide and pentasaccharide, acceptor lipids are probably Manbeta-GlcNAc-GlcNAc-pyrophosphoryldolichol and Man2alpha-Manbeta-GlcNAc-GlcNAc-pyrophosphoryldolichol
heptasaccharide-lipid as product, probably Man5GlcNAc2 as heptasaacharide
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GDP-mannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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acceptor isolated from pig liver
heptasaccharide-lipid as product, probably Man5GlcNAc2 as heptasaacharide
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GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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involved in biosynthesis of lipid-linked oligosaccharides up to (Man)5-(GlcNAc)2, involved in the production of two 1,2-linked mannosyl residues in mammalian lipid-linked tetradecasaccharide of the structure (Glc)3(Man)9(GlcNAc)2, the major precursor for eukaryotic en-bloc-glycosylation of asparagin-linked glycoproteins
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GDPmannose + oligosaccharide-lipid acceptor
GDP + alpha-mannosyl-1,2-oligosaccharide-lipid
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biosynthesis of oligosaccharide-lipids
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involved in asparagine-linked glycosylation, reaction proceeds in the endoplasmatic reticulum, role of the ALG9 step in downstream ER and Golgi N-glycan processing events
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additional information
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Alg11 mannosyltransferase shows no activity with Man-beta1,4-GlcNAc-beta1,4-GlcNAc-diphosphodolichol
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additional information
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Alg11 mannosyltransferase shows no activity with Man-beta1,4-GlcNAc-beta1,4-GlcNAc-diphosphodolichol
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additional information
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chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins. Comparison to the reaction of dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A (EC 2.4.99.18)
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additional information
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chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins. Comparison to the reaction of dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A (EC 2.4.99.18)
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additional information
additional information
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no sugar donor: mannosylphosphorylretinol
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additional information
additional information
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no substrate: dolichol-phosphat
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additional information
additional information
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(Man)6-(GlcNAc)2 precursor of enzyme
Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-2)Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAcalpha/beta is the product of the middle-arm terminal alpha1,2-mannosyltransferase Alg9p
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additional information
additional information
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no substrate: dolichol-phosphat
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additional information
additional information
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no sugar donor: mannosylphosphoryldolichol
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?