2.4.1.131: GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

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For detailed information about GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase, go to the full flat file.

Reaction

2 GDP-alpha-D-mannose +

Synonyms

Alg11, Alg2 mannosyltransferase, At2G40190, galactomannan deficiency protein 3, GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, gmd3, guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase, hALG11, LEW3, mannosyltransferase, guanosine diphosphomannose-oligosaccharide-lipid, oligosaccharide-lipid mannosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.131 GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

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2	Activating Compound
3418	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
16	Disease/ Diagnostics
5	General Information
17	Inhibitors
4	KM Value [mM]
13	Localization
4	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
16	Organism
6	Pathway
6	PDB ID
5	pH Optimum
1	Posttranslational Modification
27	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
15	Reference
13	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
27	Substrates and Products (Substrate)
2	Subunits
18	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

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Cloned on EC 2.4.1.131 - GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Schizosaccharomyces pombe

O74878

710691

ALG9 gene encodes a middle-arm terminal alpha1,2-mannosyltransferase Alg9p

Saccharomyces cerevisiae

-

638572

construction of a plasmid pREP1+/-ALG11HA for the expression of Saccharomyces cerevisiae ALG11 in Schizosaccharomyces pombe and introducing it into gmd3 mutant. The gmd3 mutant, carrying pREP+/-ALG11HA, grows at 37°C, whereas the gmd3 mutant, carrying vector pREP1 alone, does not. The defect in acid phosphatase glycosylation of gmd3 mutant is also suppressed by Saccharomyces cerevisiae ALG11. The gmd3+/alg11+ gene is a functional homologue of the Saccharomyces cerevisiae ALG11 gene

Saccharomyces cerevisiae

P53954

710691

gene ALG11, recombinant expression of N-terminally His10-tagged enzyme in Escherichia coli strain BL21-Gold (DE3)

Saccharomyces cerevisiae

P53954

759307

overexpression in Escherichia coli. Two Alg2 constructs are expressed and isolated, one with the N-terminal TRX domain and C-terminal His and V5 epitope tags and the other with only an N-terminal His tag

Saccharomyces cerevisiae

P53954

707472

retroviral expression of human wild-type and mutated ALG11 cDNA in patient-derived fibroblasts as well as using a yeast alg11 deletion strain as a heterologous expression system for hALG11 variants

Homo sapiens

Q2TAA5

708657

transformation of the LEW3 gene into the yeast mutant alg11, which exhibits a lowtemperature-sensitive phenotype and grows slowly at and below 30°C but normally at 37°C. Expression of LEW3 partially complements the slow-growth phenotype of the yeast mutant alg11, suggesting that the plant ALG11 homolog is able to partially substitute for the function of ALG11 in yeast

Arabidopsis thaliana

-

710284