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2.4.1.122: N-acetylgalactosaminide beta-1,3-galactosyltransferase

This is an abbreviated version!
For detailed information about N-acetylgalactosaminide beta-1,3-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.122

Reaction

UDP-alpha-D-galactose
+
N-acetyl-alpha-D-galactosaminyl-R
=
UDP
 +
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R

Synonyms

3betaGal-T4, beta-galactosyltransferase, C1beta3GalT, C1GalT, C1GALT1, C1GalTA, Ce-T-synthase, core 1 beta1,3-galactosyltransferase, core 1 beta1,3-galactosyltrasferase 1, core 1 beta3-Gal-T, core 1 beta3-Gal-transferase, core 1 galactosyltransferase A, core 1 GalT, core 1 synthase, core 1 transferase, core 1 UDP-alpha-galactose (UDP-Gal):GalNAca1-Ser/Thr beta1,3-galactosyltransferase, core-1 beta3GalT, dC1beta3GalT1, dC1GalT1, EC 2.4.1.307, galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, mucin-type core-1 beta1-3 galactosyltransferase, O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase, T-synthase, UDP-Gal:GalNAc-alpha-Ser/Thr beta3-galactosyltransferase, UDP-Gal:glycoprotein-alpha-GalNAc beta3 galactosyltransferase, UDP-Gal:N-acetylgalactosaminide mucin:beta1,3-galactosyltransferase, UDP-galactose:glycoprotein-alpha-GalNAc beta3-galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-galactosyltransferase, WbnJ

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase

Cloned

Cloned on EC 2.4.1.122 - N-acetylgalactosaminide beta-1,3-galactosyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of the C-terminal catalytic domain (amino acids 44-388) of C2GalTA into the vector pMT(1B) and transfected into S2 cells
DNA and amino acid sequence determination
DNA and amino acid sequence determination and analysis, transient functional expression in human 293T cells as wild-type and soluble, i.e. secreted into the medium, epitope-tagged protein, stable functional expression of the soluble epitope-tagged enzyme in CHO-K1 and Lec1-CHO cells
DNA sequence determination, functional expression in human LSC cells
expressed in HEK-293T cells
-
expressed in wheat germ cell-free translation system
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expression as FLAG-tagged proteins in Sf9 insect cells
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functional expression in human LSC cells
functional expression in Spodoptera frugiperda Sf9cells via baculovirus infection
generation of mutant mice, oocyte-specific deletion of T-synthase
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genetic interaction between dGlcAT-P and dC1GalT1
soluble T-synthase is made by co-expressing N-terminal HPC4 epitope-tagged soluble T-synthase with wild-type full-length Cosmc in Hi-5 insect cells using the Baculovirus system
-