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2.4.1.122: N-acetylgalactosaminide beta-1,3-galactosyltransferase

This is an abbreviated version!
For detailed information about N-acetylgalactosaminide beta-1,3-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.122

Reaction

UDP-alpha-D-galactose
+
N-acetyl-alpha-D-galactosaminyl-R
=
UDP
 +
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R

Synonyms

3betaGal-T4, beta-galactosyltransferase, C1beta3GalT, C1GalT, C1GALT1, C1GalTA, Ce-T-synthase, core 1 beta1,3-galactosyltransferase, core 1 beta1,3-galactosyltrasferase 1, core 1 beta3-Gal-T, core 1 beta3-Gal-transferase, core 1 galactosyltransferase A, core 1 GalT, core 1 synthase, core 1 transferase, core 1 UDP-alpha-galactose (UDP-Gal):GalNAca1-Ser/Thr beta1,3-galactosyltransferase, core-1 beta3GalT, dC1beta3GalT1, dC1GalT1, EC 2.4.1.307, galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, mucin-type core-1 beta1-3 galactosyltransferase, O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase, T-synthase, UDP-Gal:GalNAc-alpha-Ser/Thr beta3-galactosyltransferase, UDP-Gal:glycoprotein-alpha-GalNAc beta3 galactosyltransferase, UDP-Gal:N-acetylgalactosaminide mucin:beta1,3-galactosyltransferase, UDP-galactose:glycoprotein-alpha-GalNAc beta3-galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-galactosyltransferase, WbnJ

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase

Substrates Products

Substrates Products on EC 2.4.1.122 - N-acetylgalactosaminide beta-1,3-galactosyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-galactose + alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
UDP + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
UDP-alpha-D-galactose + alpha-D-GalNAc-OMe
UDP + alpha-D-Gal-(1->3)-alpha-D-GalNAc-OMe
show the reaction diagram
UDP-alpha-D-galactose + Galbeta1-3GalNAcalpha1-4-nitrophenol
?
show the reaction diagram
-
-
-
?
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-epidermal growth factor receptor
show the reaction diagram
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R
UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
show the reaction diagram
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-A
UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-A
show the reaction diagram
-
synthetic peptide
-
-
?
UDP-galactose + A-P-(N-acetyl-D-galactosaminyl)T-S-S-S
UDP + A-P-(beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl)T-S-S-S
show the reaction diagram
-
synthetic peptide
-
-
?
UDP-galactose + Ac-GHA-(GalNAcalpha1-)TSLPVTG-NH2
UDP + Ac-GHA-(Galbeta1-3GalNAcalpha1-)TSLPVTG-NH2
show the reaction diagram
pH 7.0, 0.2 mM, 750% activity in H292-cells, 550% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-SCSTGHA-(GalNAcalpha1-)TSG-NH2
UDP + Ac-SCSTGHA-(Galbeta-1-3GalNAcalpha1-)TSG-NH2
show the reaction diagram
pH 7.0, 0.2 mM, 50% activity in H292-cells, 40% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-STGHA-(GalNAcalpha1-)TSLPG-NH2
UDP + Ac-STGHA-(Galbeta1-3GalNAcalpha1-)TSLPG-NH2
show the reaction diagram
pH 7.0, 0.2 mM, 425% activity in H292-cells, 275% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-SVS-(GalNAcalpha1-)TGHATSG-NH2
UDP + Ac-SVS-(Galbeta1-3GalNAcalpha1-)TGHATSG-NH2
show the reaction diagram
pH 7.0, 0.2 mM, 300% activity in H292-cells, 450% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + Ac-TSSVS-(GalNAcalpha1-)TGHAG-NH2
UDP + Ac-TSSVS-(Galbeta1-3GalNAcalpha1-)TGHAG-NH2
show the reaction diagram
pH 7.0, 0.2 mM, 400% activity in H292-cells, 4000% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + asialo bovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo bovine submaxillary mucin
show the reaction diagram
-
-
-
?
UDP-galactose + asialo ovine submaxillary mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo ovine submaxillary mucin
show the reaction diagram
UDP-galactose + asialo-agalacto-alpha1-acid glycoprotein
UDP + galactosyl-beta-1,3-asialo-agalacto-alpha1-acid glycoprotein
show the reaction diagram
-
-
-
-
?
UDP-galactose + asialo-agalacto-glycophorin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo-agalacto-glycophorin
show the reaction diagram
-
-
-
?
UDP-galactose + asialo-mucin of Cowper's gland
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-asialo-mucin of Cowper's gland
show the reaction diagram
-
-
-
?
UDP-galactose + benzyl 2-(acetylamino)-2-deoxy-alpha-D-galactopyranoside
UDP + benzyl 2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside
show the reaction diagram
pH 7.0, 2 mM, 100% activity in H292-cells, 100% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + GalNAcalpha-Ser-Cy5
UDP + ?
show the reaction diagram
-
-
-
-
?
UDP-galactose + GalNAcalpha1-O-phenyl
?
show the reaction diagram
the enzyme is capable of utilizing UDP-Gal as the donor for the transfer of Gal residues to GalNAcalpha-1-O-phenyl and GalNAcalpha1-Ser/Thr for synthesizing core 1 structure Galbeta1-3GalNAcalpha1-R
-
-
?
UDP-galactose + ganglioside Gg3
UDP + galactosyl-beta-1,3-ganglioside Gg3
show the reaction diagram
i.e. GalNAcbeta1,4-Galbeta1,4-Glcbeta1-ceramide
-
?
UDP-galactose + ganglioside GM2
UDP + galactosyl-beta-1,3-ganglioside GM2
show the reaction diagram
UDP-galactose + glycophorin
?
show the reaction diagram
-
-
-
-
?
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine
show the reaction diagram
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
show the reaction diagram
UDP-galactose + immunglobulin A1
?
show the reaction diagram
-
-
-
-
?
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
show the reaction diagram
UDP-galactose + N-acetyl-alpha-D-galactosaminyl-phenyl
UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-phenyl
show the reaction diagram
UDP-galactose + N-acetyl-D-galactosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
show the reaction diagram
UDP-galactose + N-acetyl-D-glucosamine
UDP + beta-D-galactosyl-1,3-N-acetyl-D-glucosamine
show the reaction diagram
-
-
-
-
?
UDP-galactose + N-acetylgalactosaminide mucin
UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
show the reaction diagram
UDP-galactose + N-acetylgalactosaminitol
UDP + beta-D-galactosyl-(1,3)-N-acetylgalactosaminitol
show the reaction diagram
-
-
-
?
UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
show the reaction diagram
UDP-galactose + salivary gland mucin 81 N-acetyl-D-galactosamine
UDP + salivary gland mucin 81 D-galactosyl-1,3-N-acetyl-D-galactosamine
show the reaction diagram
UDP-galactose + TTTV-(GalNAcalpha1-)TPTPTG
UDP + TTTV-(Galbeta1-3GalNAcalpha1-)TPTPTG
show the reaction diagram
pH 7.0, 0.2 mM, 50% activity in H292-cells, 90% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + TTTVTP-(GalNAcalpha1-)TPTG
UDP + TTTVTP-(Galbeta1-3GalNAcalpha1-)TPTG
show the reaction diagram
pH 7.0, 0.2 mM, 110% activity in H292-cells, 60% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
UDP-galactose + TTTVTPTP-(GalNAcalpha1-)TG
UDP + TTTVTPTP-(Galbeta1-3GalNAcalpha1-)TG
show the reaction diagram
pH 7.0, 0.2 mM, 65% activity in H292-cells, 60% activity in A549 cells relative to 1-O-benzyl-N-acetyl-D-galactosamine
-
-
?
additional information
?
-