2.4.1.122: N-acetylgalactosaminide beta-1,3-galactosyltransferase

This is an abbreviated version!
For detailed information about N-acetylgalactosaminide beta-1,3-galactosyltransferase, go to the full flat file.

Reaction

Synonyms

3betaGal-T4, beta-galactosyltransferase, C1beta3GalT, C1GalT, C1GALT1, C1GalTA, Ce-T-synthase, core 1 beta1,3-galactosyltransferase, core 1 beta1,3-galactosyltrasferase 1, core 1 beta3-Gal-T, core 1 beta3-Gal-transferase, core 1 galactosyltransferase A, core 1 GalT, core 1 synthase, core 1 transferase, core 1 UDP-alpha-galactose (UDP-Gal):GalNAca1-Ser/Thr beta1,3-galactosyltransferase, core-1 beta3GalT, dC1beta3GalT1, dC1GalT1, EC 2.4.1.307, galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, mucin-type core-1 beta1-3 galactosyltransferase, O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase, T-synthase, UDP-Gal:GalNAc-alpha-Ser/Thr beta3-galactosyltransferase, UDP-Gal:glycoprotein-alpha-GalNAc beta3 galactosyltransferase, UDP-Gal:N-acetylgalactosaminide mucin:beta1,3-galactosyltransferase, UDP-galactose:glycoprotein-alpha-GalNAc beta3-galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-galactosyltransferase, WbnJ

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase

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Results	in table
4	Activating Compound
2674	AA Sequence
3	Application
1	CAS Registry Number
15	Cloned(Commentary)
1053	Disease/ Diagnostics
1	Expression
21	General Information
1	General Stability
7	Inhibitors
10	KM Value [mM]
19	Localization
7	Metals/Ions
8	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
43	Organism
9	Pathway
2	PDB ID
9	pH Optimum
2	pH Range
2	Posttranslational Modification
1	Protein Variants
8	Purification (Commentary)
3	Reaction
3	Reaction Type
38	Reference
1	Renatured (Commentary)
72	Source Tissue
15	Specific Activity [micromol/min/mg]
1	Storage Stability
91	Substrates and Products (Substrate)
4	Subunits
64	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

Activating Compound

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Activating Compound on EC 2.4.1.122 - N-acetylgalactosaminide beta-1,3-galactosyltransferase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Cosmc

Homo sapiens

-

specific molecular chaperone

690706

-

lactacystin

Homo sapiens

-

treatment with 0.01 mM lactacystin results in the increased expression of C1GalT protein

690706

Triton X-100

Sus scrofa

-

activation and stabilization, unstable without

638318

additional information

Drosophila melanogaster

Q7K237

Cosmc (also known as C1GALT1C1), an endoplasmic reticulum chaperone, is essential for the precise folding and activity of C1GalT1 in mammals. In contrast to mammalian orthologues, Drosophila dC1GalT1 does not require a chaperone such as Cosmc

759109

-