2.4.1.122: N-acetylgalactosaminide beta-1,3-galactosyltransferase

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For detailed information about N-acetylgalactosaminide beta-1,3-galactosyltransferase, go to the full flat file.

Reaction

Synonyms

3betaGal-T4, beta-galactosyltransferase, C1beta3GalT, C1GalT, C1GALT1, C1GalTA, Ce-T-synthase, core 1 beta1,3-galactosyltransferase, core 1 beta1,3-galactosyltrasferase 1, core 1 beta3-Gal-T, core 1 beta3-Gal-transferase, core 1 galactosyltransferase A, core 1 GalT, core 1 synthase, core 1 transferase, core 1 UDP-alpha-galactose (UDP-Gal):GalNAca1-Ser/Thr beta1,3-galactosyltransferase, core-1 beta3GalT, dC1beta3GalT1, dC1GalT1, EC 2.4.1.307, galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, mucin-type core-1 beta1-3 galactosyltransferase, O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta3-galactosyltransferase, T-synthase, UDP-Gal:GalNAc-alpha-Ser/Thr beta3-galactosyltransferase, UDP-Gal:glycoprotein-alpha-GalNAc beta3 galactosyltransferase, UDP-Gal:N-acetylgalactosaminide mucin:beta1,3-galactosyltransferase, UDP-galactose:glycoprotein-alpha-GalNAc beta3-galactosyltransferase, uridine diphosphogalactose-mucin beta-(1-3)-galactosyltransferase, WbnJ

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase

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Results	in table
4	Activating Compound
2674	AA Sequence
3	Application
1	CAS Registry Number
15	Cloned(Commentary)
1053	Disease/ Diagnostics
1	Expression
21	General Information
1	General Stability
7	Inhibitors
10	KM Value [mM]
19	Localization
7	Metals/Ions
8	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
43	Organism
9	Pathway
2	PDB ID
9	pH Optimum
2	pH Range
2	Posttranslational Modification
1	Protein Variants
8	Purification (Commentary)
3	Reaction
3	Reaction Type
38	Reference
1	Renatured (Commentary)
72	Source Tissue
15	Specific Activity [micromol/min/mg]
1	Storage Stability
91	Substrates and Products (Substrate)
4	Subunits
64	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

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RENATURED/Commentary

ORGANISM

UNIPROT

LITERATURE

the chaperone Cosmc promotes renaturation of denatured T-synthase in vitro, HPC4-tagged soluble T-synthase is denatured in 1 ml of 6 M guanidinium hydrochloride, pH 7.2 for 90 min at room temperature, the sample is diluted 100times in reconstitution buffer (10 mM HEPES, 150 mM NaCl, 12 mM MgCl2, pH 7.8), reconstitution is initiated by the addition of 6
His-sCosmc and ATP where the final concentration is 2.27 microM and 5 mM, reaction is incubated for 45 min at room temperature, 6
His-sCosmc can cause up to 75% restoration of heat-denatured HPC4-tagged soluble T-synthase activity depending on how long the protein is heat-treated, and that it can restore 30% of activity to HPC4-tagged soluble T-synthase denatured by guanidinium hydrochloride treatment

Homo sapiens

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704683