2.3.3.10: hydroxymethylglutaryl-CoA synthase

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For detailed information about hydroxymethylglutaryl-CoA synthase, go to the full flat file.

Reaction

Synonyms

(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase I, 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl-CoA synthase 2, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl_coenzyme A synthase, 3-hydroxyl-3-methyl-glutaryl-CoA synthase, acetoacetyl coenzyme A transacetase, beta-hydroxy-beta-methylglutaryl-CoA synthase, BjHMGS1, BjHMGS2, BjHMGS3, BjHMGS4, EC 4.1.3.5, GbHMGS2, GhHMGS1A, GhHMGS1D, GhHMGS2D, GhHMGS3A, GhHMGS3D, HGMS, HMG-CoA, HMG-CoA synthase, HMG-CoA synthase 1, HMG-CoS synthase, HMGCS, HMGCS1, HMGCS2, HMGS, HMGS-2, HMGS1, HMGS2, hydroxy-methylglutaryl coenzyme-A synthase, hydroxymethylglutaryl CoA synthase 2, hydroxymethylglutaryl CoA synthetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme, hydroxymethylglutaryl-CoA synthase, hydroxymethylglutaryl-coenzyme A synthase, LcHMGS, mvaS

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.3 Acyl groups converted into alkyl groups on transfer

                2.3.3.10 hydroxymethylglutaryl-CoA synthase

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Results	in table
8	Activating Compound
6579	AA Sequence
14	Application
1	CAS Registry Number
43	Cloned(Commentary)
3	Cofactor
9	Crystallization (Commentary)
837	Disease/ Diagnostics
11	Expression
24	General Information
6	General Stability
2	IC50 Value
132	Inhibitors
1	kcat/KM [mM/s]
49	Ki Value [mM]
110	KM Value [mM]
204	Localization
6	Metals/Ions
56	Molecular Weight [Da]
178	Natural Substrates/ Products (Substrates)
554	Organism
16	Pathway
48	PDB ID
12	pH Optimum
3	pH Range
2	pI Value
34	Protein Variants
40	Purification (Commentary)
1	Reaction
7	Reaction Type
208	Reference
143	Source Tissue
31	Specific Activity [micromol/min/mg]
13	Storage Stability
246	Substrates and Products (Substrate)
29	Subunits
199	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
11	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 2.3.3.10 - hydroxymethylglutaryl-CoA synthase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

45

Haloferax volcanii

D4GWR6

in the presence of an excess of acetyl-CoA, the half-life of the active enzyme is 27 h

727772

90

Pyrococcus furiosus

-

30 min, 39% loss of activity

745472