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2.3.3.10: hydroxymethylglutaryl-CoA synthase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA synthase, go to the full flat file.

Word Map on EC 2.3.3.10

Reaction

acetyl-CoA
+
H2O
+
acetoacetyl-CoA
=
(S)-3-hydroxy-3-methylglutaryl-CoA
+
CoA

Synonyms

(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase, 3-hydroxy-3-methylglutaryl CoA synthase I, 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl-CoA synthase 2, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl_coenzyme A synthase, 3-hydroxyl-3-methyl-glutaryl-CoA synthase, acetoacetyl coenzyme A transacetase, beta-hydroxy-beta-methylglutaryl-CoA synthase, BjHMGS1, BjHMGS2, BjHMGS3, BjHMGS4, EC 4.1.3.5, GbHMGS2, GhHMGS1A, GhHMGS1D, GhHMGS2D, GhHMGS3A, GhHMGS3D, HGMS, HMG-CoA, HMG-CoA synthase, HMG-CoA synthase 1, HMG-CoS synthase, HMGCS, HMGCS1, HMGCS2, HMGS, HMGS-2, HMGS1, HMGS2, hydroxy-methylglutaryl coenzyme-A synthase, hydroxymethylglutaryl CoA synthase 2, hydroxymethylglutaryl CoA synthetase, hydroxymethylglutaryl coenzyme A synthase, hydroxymethylglutaryl coenzyme A-condensing enzyme, hydroxymethylglutaryl-CoA synthase, hydroxymethylglutaryl-coenzyme A synthase, LcHMGS, mvaS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.10 hydroxymethylglutaryl-CoA synthase

Molecular Weight

Molecular Weight on EC 2.3.3.10 - hydroxymethylglutaryl-CoA synthase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
105000
-
sedimentation equlibrium
111000
-
gel filtration
116000
gel filtration
119300
-
sedimentation velocity and light-scattering
120000
-
gel filtration
130000
37500
mass spectrometric sequencing
42000
-
2 * 42000, calculated from amino acid sequence
45000
-
2 * 45000, SDS-PAGE
47900
-
2 * 47900, SDS-PAGE
50000
50100
calculated from sequence
50700
calculated from sequence
51040
-
predicted from cDNA sequence
51280
x * 51280, calculated from amino acid sequence
51975
x * 51975, matrix-assisted laser desorption ionization-time of flight mass spectrometry
52000
-
2 * 52000, mitochondrial synthase, synthase I, SDS-PAGE
52400
x * 52400, SDS-PAGE
53000
55000
-
2 * 55000, synthase II, SDS-PAGE
55500
-
SDS-PAGE
56000
-
recombinant enzyme, epressed in Escherichia coli
56800
determined by MALDI-TOF mass spectrometry
57000
-
2 * 57000, gel filtration
57250
-
deduced amino acid sequence
57290
-
deduced amino acid sequence
57370
-
deduced amino acid sequence
57490
-
deduced amino acid sequence
57600
58000
-
2 * 58000, synthases III and IV, SDS-PAGE
65000
x * 65000, SDS-PAGE
83900
-
analytical ultracentrifugation
84300
-
calculated from amino acid sequence
88000
-
gel filtration
90000
-
gel filtration, synthase I
94000 - 100000
-
gel filtration, synthase II
94600
-
sedimentation equilibrium
96000
-
gel filtration
96000 - 105000
-
gel filtration, mitochondrial synthase