Reference on EC 2.3.3.10 - hydroxymethylglutaryl-CoA synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Middleton, B.
The kinetic mechanism of 3-hydroxy-3-methylglutaryl-coenzyme a synthase from baker's yeast
Biochem. J.
126
35-47
1972
Saccharomyces cerevisiae
Middleton, B.; Tubbs, P.K.
The purification and some properties of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from baker's yeast
Biochem. J.
126
27-34
1972
Saccharomyces cerevisiae
Allred, J.B.
Properties and subcellular distribution of enzymes required for acetoacetate biosynthesis in chicken liver
Biochim. Biophys. Acta
297
22-30
1973
Cavia porcellus, Gallus gallus, Rattus norvegicus
Cornforth, J.W.; Phillips, G.T.
Substrate stereochemistry of 3-hydroxy-3-methylglutaryl-coenzyme A synthase
Eur. J. Biochem.
42
591-604
1974
Saccharomyces cerevisiae, Rattus norvegicus
Clinkenbeard, K.D.; Sugiyama, T.; Lane, M.D.
Cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase from chicken liver
Methods Enzymol.
35 B
160-167
1975
Saccharomyces cerevisiae, Gallus gallus
-
Clinkenbeard, K.D.; Sugiyama, T.; Reed, W.D.; Lane, M.D.
Cyoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from liver
J. Biol. Chem.
250
3124-3135
1975
Saccharomyces cerevisiae, Gallus gallus, Columba livia, Meleagris gallopavo, Rattus norvegicus
-
Middleton, B.; Tubbs, P.K.
3-Hydroxy-3-methylglutaryl-CoA synthase from baker's yeast
Methods Enzymol.
35 B
173-177
1975
Saccharomyces cerevisiae
-
Miziorko, H.M.; Clinkenbeard, K.D.; Reed, W.D.; Lane, M.D.
3-Hydroxy-3-methylglutaryl coenzyme A synthase
J. Biol. Chem.
250
5768-5773
1975
Saccharomyces cerevisiae, Gallus gallus
Reed, W.D.; Clinkenbeard, K.D.; Lane, M.D.
Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver
J. Biol. Chem.
250
3117-3123
1975
Gallus gallus, Rattus norvegicus
Reed, W.D.; Lane, M.D.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase from chicken liver
Methods Enzymol.
35 B
155-160
1975
Gallus gallus
-
Page, M.A.; Tubbs, P.K.
Some properties of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from ox liver
Biochem. J.
173
925-928
1978
Bos taurus, Saccharomyces cerevisiae, Gallus gallus
Menahan, L.A.; Hron, W.T.; Hinkelman, D.G.; Miziorko, H.M.
Interrelationships between 3-hydroxy-3-methylglutaryl-CoA synthase, aetoacetyl-CoA and ketogenesis
Eur. J. Biochem.
119
287-296
1981
Gallus gallus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Lowe, D.M.; Tubbs, P.K.
3-Hydroxy-3-methylglutaryl-coenzyme A synthase from ox liver
Biochem. J.
227
591-599
1985
Bos taurus, Saccharomyces cerevisiae, Gallus gallus
Lowe, D.M.; Tubbs, P.K.
Succinylation and inactivation of 3-hydroxy-3-methylglutaryl-CoA synthase by succinyl-CoA and its possible relevance to the control of ketogenesis
Biochem. J.
232
37-42
1985
Bos taurus
Miziorko, H.M.; Behnke, C.E.
Active-site directed inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by 3-chloropropionyl coenzyme A
Biochemistry
34
3174-3179
1985
Gallus gallus
-
Greenspan, M.D.; Yudkovitz, J.B.; Lo, C.Y.L.; Chen, J.S.; Alberts, A.W.; Hunt, V.M.; Chang, M.N.; Yang, S.S.; Thompson, K.L.; Chiang, Y.C.P.; Chabala, J.C.; Monaghan, R.L.; Schwartz, R.L.
Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L659,699
Proc. Natl. Acad. Sci. USA
84
7488-7492
1987
Gallus gallus, Cricetulus griseus, Homo sapiens, Rattus norvegicus
Miziorko, H.M.
3-Hydroxy-3-methylglutaryl-CoA synthase from chicken liver
Methods Enzymol.
110
19-26
1988
Gallus gallus
Mayer, R.J.; Louis-Flamberg, P.; Elliott, J.D.; Fisher, M.; Leber, J.
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones
Biochem. Biophys. Res. Commun.
169
610-616
1990
Rattus norvegicus
Greenspan, M.D.; Bull, H.B.; Yudkovitz, J.B.; Hanf, D.P.; Alberts, A.W.
Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme
Biochem. J.
289
889-895
1993
Mesocricetus auratus, Mus musculus, Rattus norvegicus
-
Misra, I.; Narasimhan, C.; Miziorko, H.M.
Avian 3-hydroxy-3-methylglutaryl-CoA synthase
J. Biol. Chem.
268
12129-12135
1993
Gallus gallus, Rattus norvegicus
Rokosz, L.L.; Boulton, D.A.; Butkiewicz, E.A.; Sanyal, G.; Cueto, M.A.; Lachance, P.A.; Hermes, J.D.
Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, andcharacterization of recombinant wild-type and cys-129 mutant enzymes
Arch. Biochem. Biophys.
312
1-13
1994
Gallus gallus, Cricetulus griseus, Homo sapiens, Rattus norvegicus
Misra, I.; Charlier, H.A.; Miziorko, H.M.
Avian cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase. Evaluation of the role of cysteines in reaction chemistry
Biochim. Biophys. Acta
1247
253-259
1995
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Cricetulus griseus (P13704), Blattella germanica (P54870), Blattella germanica (P54961)
Montamat, F.; Guilloton, M.; Karst, F.; Delrot, S.
Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase
Gene
167
197-201
1995
Arabidopsis thaliana, Catharanthus roseus, Gallus gallus, Cricetulus griseus, Homo sapiens, Raphanus sativus, Rattus norvegicus
Scharnagl, H.; Mrz, W.; Schliack, M.; Lser, R.; Gross, W.
A novel assay of cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using reversed-phase ion-pair chromatography: demonstration that Lifibrol (K12.148) modulates the enzyme activity
J. Lipid Res.
36
622-627
1995
Bos taurus, Gallus gallus, Cricetulus griseus, Homo sapiens, Mesocricetus auratus, Rattus norvegicus
Misra, I.; Miziorko, H.M.
Evidence for the interaction of avian 3-hydroxy-3-methylglutaryl-CoA synthase H264 with acetoacetyl-CoA
Biochemistry
35
9610-9616
1996
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Blattella germanica (P54870), Blattella germanica (P54961)
Cabano, J.; Buesa, C.; Hegardt, F.G.; Marrero, P.F.
Catalytic properties of recombinant 3-hydroxy-3-methylglutaryl coenzyme A synthase-1 from Blattella germanica
Insect Biochem. Mol. Biol.
27
499-505
1997
Blattella germanica, Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Diploptera punctata, Locusta migratoria
Chun, K.Y.; Vinarov, D.A.; Miziorko, H.M.
3-Hydroxy-3-methylglutaryl-CoA synthase: Participation of invariant acidic residues in formation of the acetyl-S-enzyme reaction intermediate
Biochemistry
39
14670-14681
2000
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P54839), Gallus gallus, Gallus gallus (P23228), Homo sapiens, Homo sapiens (P54868), Homo sapiens (Q01581), Mesocricetus auratus, Methanothermobacter thermautotrophicus, Sus scrofa (O02734), Borreliella burgdorferi (O51626), Cricetulus griseus (P13704), Rattus norvegicus (P17425), Rattus norvegicus (P22791), Mus musculus (P54869), Blattella germanica (P54870), Blattella germanica (P54961), Caenorhabditis elegans (P54871), Arabidopsis thaliana (P54873), Schizosaccharomyces pombe (P54874), Pinus sylvestris (P93773)
Chun, K.Y.; Vinarov, D.A.; Zajicek, J.; Miziorko, H.M.
3-hydroxy-3-methylglutaryl-CoA synthase. A role for glutamate 95 in general acid/base catalysis of C-C bond formation
J. Biol. Chem.
275
17946-17953
2000
Gallus gallus, Gallus gallus (P23228), Homo sapiens, Homo sapiens (P54868), Methanothermobacter thermautotrophicus, Sus scrofa (O02734), Borreliella burgdorferi (O51626), Rattus norvegicus (P22791), Mus musculus (P54869), Blattella germanica (P54870), Blattella germanica (P54961), Arabidopsis thaliana (P54873), Schizosaccharomyces pombe (P54874), Pinus sylvestris (P93773)
Vinarov, D.A.; Miziorko, H.M.
3-Hydroxy-3-methylglutaryl-coenzyme A synthase reaction intermediates: Detection of a covalent tetrahedral adduct by differential isotope shift 13C nuclear magnetic resonance spectroscopy
Biochemistry
39
3360-3368
2000
Gallus gallus
Barrero, M.J.; Alho, C.S.; Ortiz, J.A.; Hegardt, F.G.; Haro, D.; Marrero, P.F.
Low activity of mitochondrial HMG-CoA synthase in liver of starved pigletsis due to low levels of protein despite high mRNA levels
Arch. Biochem. Biophys.
385
364-371
2001
Rattus norvegicus, Sus scrofa, Rattus norvegicus Sprague-Dawley
Casals, N.; Buesa, C.; Marrero, P.F.; Belles, X.; Hegardt, F.G.
3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene
Insect Biochem. Mol. Biol.
31
425-433
2001
Blattella germanica
Sutherlin, A.; Hedl, M.; Sanchez-Neri, B.; Burgner, J.W.; Stauffacher, C.V.; Rodwell, V.W.
Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis
J. Bacteriol.
184
4065-4070
2002
Blattella germanica, Borreliella burgdorferi, Bos taurus, Streptomyces sp., Gallus gallus, Streptococcus pneumoniae, Enterococcus faecalis, Homo sapiens, Mesocricetus auratus, Staphylococcus aureus, Mus musculus, Rattus norvegicus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Streptococcus pyogenes, Sus scrofa
Misra, I.; Wang, C.Z.; Miziorko, H.M.
The influence of conserved aromatic residues in 3-hydroxy-3-methylglutaryl-CoA synthase
J. Biol. Chem.
12
12
2003
Gallus gallus
-
Hegardt, F.G.
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis
Biochem. J.
338
569-582
1999
Rattus norvegicus, Sus scrofa
Nagegowda, D.A.; Bach, T.J.; Chye, M.L.
Brassica juncea 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase 1: expression and characterization of recombinant wild-type and mutant enzymes
Biochem. J.
383
517-527
2004
Brassica juncea
Madsen, L.; Garras, A.; Asins, G.; Serra, D.; Hegardt, F.G.; Berge, R.K.
Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation
Biochem. Pharmacol.
57
1011-1019
1999
Rattus norvegicus
Tomoda, H.; Ohbayashi, N.; Morikawa, Y.; Kumagai, H.; Omura, S.
Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase
Biochim. Biophys. Acta
1636
22-28
2004
Cricetinae, Rattus norvegicus
Campobasso, N.; Patel, M.; Wilding, I.E.; Kallender, H.; Rosenberg, M.; Gwynn, M.N.
Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism
J. Biol. Chem.
279
44883-44888
2004
Staphylococcus aureus
Alex, D.; Bach, T.J.; Chye, M.L.
Expression of Brassica juncea 3-hydroxy-3-methylglutaryl CoA synthase is developmentally regulated and stress-responsive
Plant J.
22
415-426
2000
Brassica juncea
Sirinupong, N.; Suwanmanee, P.; Doolittle, R.F.; Suvachitanont, W.
Molecular cloning of a new cDNA and expression of 3-hydroxy-3-methylglutaryl-CoA synthase gene from Hevea brasiliensis
Planta
221
502-512
2005
Hevea brasiliensis
Nagegowda, D.A.; Ramalingam, S.; Hemmerlin, A.; Bach, T.J.; Chye, M.L.
Brassica juncea HMG-CoA synthase: localization of mRNA and protein
Planta
221
844-856
2005
Brassica juncea, Brassica juncea BjHMGS2, Brassica juncea BjHMGS3, Brassica juncea BjHMGS1, Brassica juncea BjHMGS4
Steussy, C.N.; Vartia, A.A.; Burgner, J.W.; Sutherlin, A.; Rodwell, V.W.; Stauffacher, C.V.
X-ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA
Biochemistry
44
14256-14267
2005
Enterococcus faecalis
Steussy, C.N.; Robison, A.D.; Tetrick, A.M.; Knight, J.T.; Rodwell, V.W.; Stauffacher, C.V.; Sutherlin, A.L.
A structural limitation on enzyme activity: the case of HMG-CoA synthase
Biochemistry
45
14407-14414
2006
Enterococcus faecalis
Bearfield, J.C.; Keeling, C.I.; Young, S.; Blomquist, G.J.; Tittiger, C.
Isolation, endocrine regulation and mRNA distribution of the 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMG-S) gene from the pine engraver, Ips pini (Coleoptera: Scolytidae)
Insect Mol. Biol.
15
187-195
2006
Ips pini (Q5EE42), Ips pini
Bode, H.B.; Ring, M.W.; Schwaer, G.; Kroppenstedt, R.M.; Kaiser, D.; Mueller, R.
3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation
J. Bacteriol.
188
6524-6528
2006
Myxococcus xanthus
Camarero, N.; Mascaro, C.; Mayordomo, C.; Vilardell, F.; Haro, D.; Marrero, P.F.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer
Mol. Cancer Res.
4
645-653
2006
Homo sapiens
Pojer, F.; Ferrer, J.L.; Richard, S.B.; Nagegowda, D.A.; Chye, M.L.; Bach, T.J.; Noel, J.P.
Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases
Proc. Natl. Acad. Sci. USA
103
11491-11496
2006
Brassica juncea
Castro, J.; Amigo, L.; Miquel, J.F.; Gaelman, C.; Crovari, F.; Raddatz, A.; Zanlungo, S.; Jalil, R.; Rudling, M.; Nervi, F.
Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease
Hepatology
45
1261-1266
2007
Homo sapiens
Liu, M.H.; Li, J.; Shen, P.; Husna, B.; Tai, E.S.; Yong, E.L.
A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin
Mol. Endocrinol.
22
1078-1092
2008
Homo sapiens
Andrew Skaff, D.; Miziorko, H.M.
A visible wavelength spectrophotometric assay suitable for high-throughput screening of 3-hydroxy-3-methylglutaryl-CoA synthase
Anal. Biochem.
396
96-102
2010
Homo sapiens
Yi, W.; Fu, P.; Fan, Z.; Aso, H.; Tian, C.; Meng, Y.; Liu, J.; Yamori, Y.; Nara, Y.; Ying, C.
Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats
Nutrition
26
1176-1180
2010
Rattus norvegicus (P22791)
Okamura, E.; Tomita, T.; Sawa, R.; Nishiyama, M.; Kuzuyama, T.
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway
Proc. Natl. Acad. Sci. USA
107
11265-11270
2010
no activity in Streptomyces albus
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Andringa, K.K.; Bajt, M.L.; Jaeschke, H.; Bailey, S.M.
Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase
Toxicol. Lett.
177
188-197
2008
Mus musculus (P54869)
Skaff, D.A.; Ramyar, K.X.; McWhorter, W.J.; Barta, M.L.; Geisbrecht, B.V.; Miziorko, H.M.
Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin
Biochemistry
51
4713-4722
2012
Enterococcus faecalis (Q9FD71), Enterococcus faecalis
Shafqat, N.; Turnbull, A.; Zschocke, J.; Oppermann, U.; Yue, W.W.
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design
J. Mol. Biol.
398
497-506
2010
Homo sapiens (P54868), Homo sapiens (Q01581), Homo sapiens
Puisac, B.; Ramos, M.; Arnedo, M.; Menao, S.; Gil-Rodriguez, M.C.; Teresa-Rodrigo, M.E.; Pie, A.; de Karam, J.C.; Wesselink, J.J.; Gimenez, I.; Ramos, F.J.; Casals, N.; Gomez-Puertas, P.; Hegardt, F.G.; Pie, J.
Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway
Mol. Biol. Rep.
39
4777-4785
2012
Homo sapiens
Wang, H.; Nagegowda, D.A.; Rawat, R.; Bouvier-Nave, P.; Guo, D.; Bach, T.J.; Chye, M.L.
Overexpression of Brassica juncea wild-type and mutant HMG-CoA synthase 1 in Arabidopsis up-regulates genes in sterol biosynthesis and enhances sterol production and stress tolerance
Plant Biotechnol. J.
10
31-42
2012
Brassica juncea
Satoh, M.; Haruta-Satoh, E.; Yamada, M.; Kado, S.; Nomura, F.
Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption
Pancreas
42
475-482
2013
Rattus norvegicus (P22791)
VanNice, J.C.; Skaff, D.A.; Wyckoff, G.J.; Miziorko, H.M.
Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea
J. Bacteriol.
195
3854-3862
2013
Haloferax volcanii (D4GWR6), Haloferax volcanii, Haloferax volcanii DSM 3757 (D4GWR6)
Chang, J.; Ning, Y.; Xu, F.; Cheng, S.; Li, X.
Research advance of 3-hydroxy-3-methylglutaryl-coenzyme A synthase in plant isoprenoid biosynthesis
J. Anim. Plant Sci.
25
1441-1450
2015
Theobroma cacao (A0A061G5Y3), Chara vulgaris (A4GKI2), Ricinus communis (B9RC08), Artemisia annua (D2WS91), Panax ginseng (F8QQQ9), Medicago truncatula (G7KER8), Camellia sinensis (H9CTV3), Picrorhiza kurrooa (I7FQY9), Siraitia grosvenorii (K7NBW5)
-
Mathews, E.S.; Mawdsley, D.J.; Walker, M.; Hines, J.H.; Pozzoli, M.; Appel, B.
Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression
J. Neurosci.
34
3402-3412
2014
Danio rerio (Q7ZWE2), Danio rerio
Liu, Y.; Zhao, Y.; Zhang, M.; Su, P.; Wang, X.; Zhang, X.; Gao, W.; Huang, L.
Cloning and characterisation of the gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase in Tripterygium wilfordii
Molecules
19
19696-19707
2014
Tripterygium wilfordii (A0A0C5ACA9), Tripterygium wilfordii
Liao, P.; Wang, H.; Hemmerlin, A.; Nagegowda, D.A.; Bach, T.J.; Wang, M.; Chye, M.L.
Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway
Plant Cell Rep.
33
1005-1022
2014
Arabidopsis thaliana (P54873), Brassica juncea (Q9M6U3), Camptotheca acuminata (B3GDB1), Catharanthus roseus, Gallus gallus (P23228), Hevea brasiliensis (Q94ET0), Hevea brasiliensis, Homo sapiens (A0A024R059), Melampsora larici-populina, Mesocricetus auratus, Pinus sylvestris (P93773), Populus trichocarpa x Populus deltoides, Rattus norvegicus (P17425), Salvia miltiorrhiza (D2DS62), Solanum lycopersicum (A9LRT6), Sus scrofa (O02734), Taxus x media (Q693N8)
Liao, P.; Wang, H.; Wang, M.; Hsiao, A.S.; Bach, T.J.; Chye, M.L.
Transgenic tobacco overexpressing Brassica juncea HMG-CoA synthase 1 shows increased plant growth, pod size and seed yield
PLoS ONE
9
e98264
2014
Brassica juncea (Q9M6U3), Brassica juncea
Kai, G.; Li, S.; Wang, W.; Lu, Y.; Wang, J.; Liao, P.; Cui, L.
Molecular cloning and expression analysis of a gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase from Camptotheca acuminata
Russ. J. Plant Physiol.
60
131-138
2013
Camptotheca acuminata (B3GDB1)
-
Tachibana, A.; Yano, Y.; Otani, S.; Taniguchi, M.
Non-radiochemical 3-hydroxy-3-methylglutaryl-coenzyme a synthase assay by reversed-phase HPLC without using ion-pair reagent
J. Ferment. Bioeng.
86
523-526
1998
Pyrococcus furiosus
-
Meng, X.; Xu, F.; Song, Q.; Ye, J.; Liao, Y.; Zhang, W.
Isolation, characterization and functional analysis of a novel 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene (GbHMGS2) from Ginkgo biloba
Acta Physiol. Plant.
40
72
2018
Ginkgo biloba (A0A2L0ARV1)
-
Wang, F.; Xiang, H.; Fischer, G.; Liu, Z.; Dupont, M.J.; Hogan, Q.H.; Yu, H.
HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury
Brain Res.
1652
62-70
2016
Rattus norvegicus (P17425), Rattus norvegicus (P22791)
Liu, W.; Zhang, Z.; Zhu, W.; Ren, Z.; Jia, L.; Li, W.; Ma, Z.
Evolutionary conservation and divergence of genes encoding 3-hydroxy-3-methylglutaryl coenzyme A synthase in the allotetraploid cotton species Gossypium hirsutum
Cells
8
412
2019
Gossypium hirsutum
Bock, T.; Kasten, J.; Mueller, R.; Blankenfeldt, W.
Crystal structure of the HMG-CoA synthase MvaS from the Gram-negative bacterium Myxococcus xanthus
ChemBioChem
17
1257-1262
2016
Myxococcus xanthus (Q1D4I1), Myxococcus xanthus, Myxococcus xanthus DK 1622 (Q1D4I1)
Tao, T.; Chen, Q.; Meng, X.; Yan, J.; Xu, F.; Chang, J.
Molecular cloning, characterization, and functional analysis of a gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase from Matricaria chamomilla
Genes Genomics
38
1179-1187
2016
Matricaria chamomilla (A0A140GL77)
-
Zhao, L.; Fan, J.; Xia, S.; Pan, Y.; Liu, S.; Qian, G.; Qian, Z.; Kang, H.B.; Arbiser, J.L.; Pollack, B.P.; Kudchadkar, R.R.; Lawson, D.H.; Rossi, M.; Abdel-Wahab, O.; Merghoub, T.; Khoury, H.J.; Khuri, F.R.; Boise, L.H.; Lonial, S.; Chen, F.; Chen, J.; Lin, R.
HMG-CoA synthase 1 is a synthetic lethal partner of BRAFV600E in human cancers
J. Biol. Chem.
292
10142-10152
2017
Homo sapiens (Q01581), Homo sapiens
Liao, P.; Lung, S.C.; Chan, W.L.; Bach, T.J.; Lo, C.; Chye, M.L.
Overexpression of HMG-CoA synthase promotes Arabidopsis root growth and adversely affects glucosinolate biosynthesis
J. Exp. Bot.
71
272-289
2020
Arabidopsis thaliana (P54873)
Cheng, S.; Wang, X.; Xu, F.; Chen, Q.; Tao, T.; Lei, J.; Zhang, W.; Liao, Y.; Chang, J.; Li, X.
Cloning, expression profiling and functional analysis of CnHMGS, a gene encoding 3-hydroxy-3-methylglutaryl coenzyme A synthase from Chamaemelum nobile
Molecules
21
316
2016
Chamaemelum nobile (A0A140GL76), Chamaemelum nobile
Uthup, T.K.; Rajamani, A.; Ravindran, M.; Saha, T.
Molecular evolution and functional characterisation of haplotypes of an important rubber biosynthesis gene in Hevea brasiliensis
Plant Biol.
18
720-728
2016
Hevea brasiliensis (A0A088SG34), Hevea brasiliensis (A0A0S3J3P1), Hevea brasiliensis (A0A0S3J3P6), Hevea brasiliensis (A9ZMZ6), Hevea brasiliensis
Liao, P.; Chen, X.; Wang, M.; Bach, T.J.; Chye, M.L.
Improved fruit alpha-tocopherol, carotenoid, squalene and phytosterol contents through manipulation of Brassica juncea 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE1 in transgenic tomato
Plant Biotechnol. J.
16
784-796
2018
Brassica juncea (Q9M6U3), Brassica juncea
Voegeli, B.; Engilberge, S.; Girard, E.; Riobe, F.; Maury, O.; Erb, T.J.; Shima, S.; Wagner, T.
Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site
Proc. Natl. Acad. Sci. USA
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3380-3385
2018
Methanothermococcus thermolithotrophicus (A0A384E143), Methanothermococcus thermolithotrophicus DSM 2095 (A0A384E143)
Wu, L.; Zhao, Y.; Zhang, Q.; Chen, Y.; Gao, M.; Wang, Y.
Overexpression of the 3-hydroxy-3-methylglutaryl-CoA synthase gene LcHMGS effectively increases the yield of monoterpenes and sesquiterpenes
Tree Physiol.
40
1095-1107
2020
Litsea cubeba (A0A6B9XY58), Litsea cubeba
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