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2.3.1.54: formate C-acetyltransferase

This is an abbreviated version!
For detailed information about formate C-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.54

Reaction

acetyl-CoA
+
formate
=
CoA
+
pyruvate

Synonyms

AF_1449, formate acetyltransferase, PFL, PFL I, Pfl1, PflB, phosphotransferase system enzyme I, pyruvate formate lyase, pyruvate formate-lyase, pyruvate-formate lyase, pyruvate:formate lyase, pyruvic formate-lyase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.54 formate C-acetyltransferase

Inhibitors

Inhibitors on EC 2.3.1.54 - formate C-acetyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
rapid, reversible inactivation, deactivation is a non-destructive transfer of an H atom equivalent to quench the glycyl radical
Acetylphosphinate
-
mechanism-based inactivator
D-Glyceraldehyde-3-phosphate
DEAE-cellulose
-
dihydroxyacetone phosphate
dioxygen
-
-
DTT
-
reversible inactivation, deactivation is a non-destructive transfer of an H atom equivalent to quench the glycyl radical
formate
-
product inhibition
HPO42-
hypophosphite
iodoacetate
-
-
methacrylate
oxamate
-
isosteric, chemically inert pyruvate analogue
S-adenosyl-L-homocysteine
SO42-
additional information
-
the putative pyruvate formate-lyase deactivase, as activity of AdhE together with an alcohol dehydrogenase and an acetaldehyde-CoA dehydrogenase activities, is not active on the enzyme PFL, it has no PFL deactivating activity
-