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2.3.1.54: formate C-acetyltransferase

This is an abbreviated version!
For detailed information about formate C-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.54

Reaction

acetyl-CoA
+
formate
=
CoA
+
pyruvate

Synonyms

AF_1449, formate acetyltransferase, PFL, PFL I, Pfl1, PflB, phosphotransferase system enzyme I, pyruvate formate lyase, pyruvate formate-lyase, pyruvate-formate lyase, pyruvate:formate lyase, pyruvic formate-lyase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.54 formate C-acetyltransferase

Activating Compound

Activating Compound on EC 2.3.1.54 - formate C-acetyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ferredoxin
-
NADPH
-
more effective for activation than NADPH, 0.02 mM NADPH activates over 80% inactive enzyme in cell-free extracts
oxamate
pyruvate
pyruvate formate lyase activating enzyme
activates the enzyme by forming a glycine radical, cf. EC 1.97.1.4
-
pyruvate formate-lyase activating enzyme
-
reduced ferredoxin
reduced flavodoxin is te better cofactor
reduced flavodoxin
a better electron donor than reduced ferredoxin
S-adenosylmethionine
Y06I
Tequatrovirus T4
-
autonomous glycyl radical cofactor, reconstituting the catalytic center of oxygen-fragmented enzyme
-
YfiD
-
additional information
-
conversion into the active form is carried out by an activating system containing a flavodoxin system and an activating enzyme (pyruvate format lyase-activase, EC 1.97.1.4)
-