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2.3.1.251: lipid IVA palmitoyltransferase

This is an abbreviated version!
For detailed information about lipid IVA palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.251

Reaction

1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
+
hexa-acyl lipid A
=
2-acyl-sn-glycero-3-phosphocholine
+
hepta-acyl lipid A

Synonyms

crcA, lipid A palmitoyltransferase, PA1343, PagP

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.251 lipid IVA palmitoyltransferase

Application

Application on EC 2.3.1.251 - lipid IVA palmitoyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
synthesis
-
deacylated lipid A, deacylated and palmitoylated lipid A, and palmitoylated lipid A species are generated in Escherichia coli cells heterologously expressing salmonellae lipid A 3-O-deacylase PagL and/or PagP, and then purified by sequential thin-layer chromatography. The purified lipid A species show m/z values that correspond to single lipid A species on mass spectrometry analysis. The modified lipid A species show reduced ability to induce cellular signaling through Toll-like receptor 4