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2.3.1.251: lipid IVA palmitoyltransferase

This is an abbreviated version!
For detailed information about lipid IVA palmitoyltransferase, go to the full flat file.

Word Map on EC 2.3.1.251

Reaction

1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine
+
hexa-acyl lipid A
=
2-acyl-sn-glycero-3-phosphocholine
 +
hepta-acyl lipid A

Synonyms

crcA, lipid A palmitoyltransferase, PA1343, PagP

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.251 lipid IVA palmitoyltransferase

Engineering

Engineering on EC 2.3.1.251 - lipid IVA palmitoyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L57Q
mutation leads to destabilizization by about 3.5 kcal/mol
S91K
mutation leads to stabilizization by about 3.0 kcal/mol
D84A
mutation does not alter protein function
D84N
mutation does not alter protein function
D86A
mutation does not alter protein function
D86N
mutation does not alter protein function
H35F
loss of catalytic activity
H35N
loss of catalytic activity
H45F
mutation does not alter protein function
S85A
mutation does not alter protein function
S85G
mutation does not alter protein function
S87A
mutation does not alter protein function
S87G
mutation does not alter protein function
K91S
-
mutation leads to 2fold reduction in the protein stability by about 3.45 kcal/mol
Q57L
-
presence of Leu confers an added 2.2 kcal/mol stabilization