Application | Comment | Organism |
---|---|---|
medicine | PagP is not required for the initial colonization of the mouse respiratory tract by Bordetella bronchiseptica, but is required for persistence of the organism within this organ | Bordetella bronchiseptica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | Bordetella bronchiseptica | - |
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | Bordetella bronchiseptica ATCC BAA-588 | - |
2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
additional information | Bordetella bronchiseptica | enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions | ? | - |
? | |
additional information | Bordetella bronchiseptica ATCC BAA-588 | enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bordetella bronchiseptica | Q7WFT9 | - |
- |
Bordetella bronchiseptica ATCC BAA-588 | Q7WFT9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Bordetella bronchiseptica | 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A | - |
Bordetella bronchiseptica ATCC BAA-588 | 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A | - |
? | |
additional information | enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions | Bordetella bronchiseptica | ? | - |
? | |
additional information | enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions | Bordetella bronchiseptica ATCC BAA-588 | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | lipid A of a PagP mutant differs from wild-type lipid A by the absence of a palmitate group in secondary acylation at the C3' position. PagP mediates modification of the lipid A as part of the overall Bvg-mediated adaptation of this organism to changing environmental conditions. PagP is not required for the initial colonization of the mouse respiratory tract by Bordetella bronchiseptica, but is required for persistence of the organism within this organ | Bordetella bronchiseptica |