2.3.1.239: 10-deoxymethynolide synthase

This is an abbreviated version!
For detailed information about 10-deoxymethynolide synthase, go to the full flat file.

Word Map on EC 2.3.1.239

2.3.1.239

venezuelae

macrolactone

14-membered

thioesterase

narbonolide

macrolide

synthases

6-deoxyerythronolide

cyclization

triketide

hexaketide

erythromycin

n-acetylcysteamine

macrocyclization

te

ketosynthase

ketoreductase

plasmid-based

synthesis

Reaction

+ 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ =

+ 6 CoA + 6 CO2 + 5 NADP⁺ + 2 H2O

Synonyms

methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.239 10-deoxymethynolide synthase

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Results	in table
106	AA Sequence
4	Application
6	Cloned(Commentary)
3	Cofactor
2	General Information
2	kcat/KM [mM/s]
3	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
26	Organism
6	Pathway
3	PDB ID
3	pH Optimum
4	Protein Variants
2	Purification (Commentary)
3	Reaction
15	Reference
15	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.3.1.239 - 10-deoxymethynolide synthase

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(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide forming)

The product, 10-deoxymethynolide, contains a 12-membered ring and is an intermediate in the biosynthesis of methymycin in the bacterium Streptomyces venezuelae. The enzyme also produces narbonolide (see EC 2.3.1.240, narbonolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis.