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2.3.1.239: 10-deoxymethynolide synthase

This is an abbreviated version!
For detailed information about 10-deoxymethynolide synthase, go to the full flat file.

Word Map on EC 2.3.1.239

Reaction

malonyl-CoA
+ 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ =
10-deoxymethynolide
 + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O

Synonyms

methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.239 10-deoxymethynolide synthase

KCat KM Value

KCat KM Value on EC 2.3.1.239 - 10-deoxymethynolide synthase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.2
(E)-(2S,4R,8R,9R)-S-2-acetamidoethyl 9-hydroxy-2,4,8-trimethyl-5-oxoundec-6-enethioate
pH 7.2, 30°C, kcat/Km-value for activity with the polyketide synthase PikAIII/polyketide synthase PikAIV complex in formation of 10-deoxymethynolide
additional information
additional information
-
steady state kinetic parameters for diketides with wild-type and mutant thioesterase domain of methymycin/picromycin synthase
-