2.3.1.239: 10-deoxymethynolide synthase

This is an abbreviated version!
For detailed information about 10-deoxymethynolide synthase, go to the full flat file.

Word Map on EC 2.3.1.239

2.3.1.239

venezuelae

macrolactone

14-membered

thioesterase

narbonolide

macrolide

synthases

6-deoxyerythronolide

cyclization

triketide

hexaketide

erythromycin

n-acetylcysteamine

macrocyclization

te

ketosynthase

ketoreductase

plasmid-based

synthesis

Reaction

+ 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ =

+ 6 CoA + 6 CO2 + 5 NADP⁺ + 2 H2O

Synonyms

methymycin/picromycin polyketide synthase, picromycin/methymycin PKS, picromycin/methymycin polyketide synthase, PICS, PikAI, PikAIII, PikAIV, pikromycin PKS, pikromycin polyketide synthase, type I polyketide synthase PikAIV

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.239 10-deoxymethynolide synthase

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Results	in table
106	AA Sequence
4	Application
6	Cloned(Commentary)
3	Cofactor
2	General Information
2	kcat/KM [mM/s]
3	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
26	Organism
6	Pathway
3	PDB ID
3	pH Optimum
4	Protein Variants
2	Purification (Commentary)
3	Reaction
15	Reference
15	Substrates and Products (Substrate)
4	Subunits
17	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Turnover Number [1/s]

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Reference on EC 2.3.1.239 - 10-deoxymethynolide synthase

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729193

Lu, H.; Tsai, S.; Khosla, C.; Cane, D.

Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

Biochemistry

12590-12597

2002

Streptomyces venezuelae

12379101

729574

Kittendorf, J.D.; Beck, B.J.; Buchholz, T.J.; Seufert, W.; Sherman, D.H.

Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase

Chem. Biol.

944-954

2007

Streptomyces venezuelae (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1)

17719493

729578

Tang, L.; Fu, H.; Betlach, M.C.; McDaniel, R.

Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase

Chem. Biol.

553-558

1999

Streptomyces venezuelae (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1), Streptomyces venezuelae

10421766

729589

Yan, J.; Gupta, S.; Sherman, D.H.; Reynolds, K.A.

Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains

ChemBioChem

1537-1543

2009

Streptomyces venezuelae (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1), Streptomyces venezuelae, Streptomyces venezuelae ATCC 15439 (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1)

19437523

729876

Yin, Y.; Lu, H.; Khosla, C.; Cane, D.E.

Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase

J. Am. Chem. Soc.

125

5671-5676

2003

Streptomyces venezuelae (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1), Streptomyces venezuelae ATCC 15439 (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1)

12733905

729878

Aldrich, C.C.; Beck, B.J.; Fecik, R.A.; Sherman, D.H.

Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates

J. Am. Chem. Soc.

127

8441-8452

2005

Streptomyces venezuelae (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1)

15941278

730470

Whicher, J.R.; Dutta, S.; Hansen, D.A.; Hale, W.A.; Chemler, J.A.; Dosey, A.M.; Narayan, A.R.; Hakansson, K.; Sherman, D.H.; Smith, J.L.; Skiniotis, G.

Structural rearrangements of a polyketide synthase module during its catalytic cycle

Nature

510

560-564

2014

Streptomyces venezuelae (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1), Streptomyces venezuelae, Streptomyces venezuelae ATCC 15439 (Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1)

24965656

736312

Chemler, J.A.; Tripathi, A.; Hansen, D.A.; ONeil-Johnson, M.; Williams, R.B.; Starks, C.; Park, S.R.; Sherman, D.H.

Evolution of efficient modular polyketide synthases by homologous recombination

J. Am. Chem. Soc.

137

10603-10609

2015

Streptomyces venezuelae, Streptomyces venezuelae ATCC 15439

26230368

736315

Hansen, D.A.; Koch, A.A.; Sherman, D.H.

Substrate controlled divergence in polyketide synthase catalysis

J. Am. Chem. Soc.

137

3735-3738

2015

Streptomyces venezuelae, Streptomyces venezuelae ATCC 15439

25730816

736316

Li, Y.; Dodge, G.J.; Fiers, W.D.; Fecik, R.A.; Smith, J.L.; Aldrich, C.C.

Functional characterization of a dehydratase domain from the pikromycin polyketide synthase

J. Am. Chem. Soc.

137

7003-7006

2015

Streptomyces venezuelae

26027428