2.3.1.206: 3,5,7-trioxododecanoyl-CoA synthase
This is an abbreviated version!
For detailed information about 3,5,7-trioxododecanoyl-CoA synthase, go to the full flat file.
Word Map on EC 2.3.1.206
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2.3.1.206
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starter
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chalcone
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pyrones
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triketide
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condensations
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alkylresorcinols
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4-coumaroyl-coa
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1,3,6,8-tetrahydroxynaphthalene
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pentaketide
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resorcinol
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cys-his-asn
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benzalacetone
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octaketide
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flaviolin
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chs-like
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huperzia
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alpha-pyrones
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olivetolic
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arborescens
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hexaketide
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resorcylic
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coa-linked
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precursor-directed
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n-methylanthraniloyl-coa
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synthesis
- 2.3.1.206
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starter
- chalcone
- pyrones
-
triketide
-
condensations
-
alkylresorcinols
- 4-coumaroyl-coa
- 1,3,6,8-tetrahydroxynaphthalene
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pentaketide
- resorcinol
-
cys-his-asn
- benzalacetone
-
octaketide
- flaviolin
-
chs-like
- huperzia
- alpha-pyrones
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olivetolic
- arborescens
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hexaketide
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resorcylic
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coa-linked
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precursor-directed
- n-methylanthraniloyl-coa
- synthesis
Reaction
3 malonyl-CoA + = 3 CoA + + 3 CO2
Synonyms
OLA synthase, olivetol synthase, olivetol-forming PKS, OLS, PKS, polyketide synthase, tetraketide synthase, TKS, type III PKS, type III polyketide synthase
ECTree
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General Information
General Information on EC 2.3.1.206 - 3,5,7-trioxododecanoyl-CoA synthase
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metabolism
physiological function
additional information
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factors might affect the timing of the hydrolysis and cyclization reactions by olivetol synthase to form an olivetolic acid-forming metabolic complex together with olivetol synthase, metabolon formation
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the enzyme is involved in the biosynthesis of cannabinoids, the glandular trichomes from female cannabis flowers are the primary site of cannabinoid biosynthesis, proposed cannabinoid biosynthetic pathway, overview. TKS synthesizes a diffusible intermediate that is converted to olivetolic acid by OAC
metabolism
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the enzyme is involved the biosynthesis of the first precursor of cannabinoids, olivetolic acid. Cannabinoid and flavonoid profiling, overview. Accumulation of cannabinoids in bracts during the growth and development of glandular trichomes from flowers, cannabinoid accumulation iscorrelated with maximum activities for an olivetol-forming PKS, developmental and defens-related regulation of cannabinoid pathway enzymes, overview
metabolism
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the polyketide synthase catalyzes the first step of cannabinoid biosynthesis, leading to olivetolic acid
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olivetolic acid is the first intermediate involved in the cannabinoid biosynthesis in Cannabis sativa leading to the acidic forms of the major cannabinoids such as DELTA9-tetrahydrocannabinolic acid and cannabinolic acid
physiological function
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polyketide synthases play an important role in the biosynthesis of secondary metabolites such as resveratrol, a candidate for cancer chemoprevention and naringenin, the precursor for flavonoids. Olivetolic acid is also be expected to be synthesized by a PKS
physiological function
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the type III PKS, i.e. tetraketide synthase, from cannabis trichomes requires the presence of a polyketide cyclase enzyme, olivetolic acid cyclase, which catalyzes a C2-C7 intramolecular aldol condensation with carboxylate retention to form olivetolic acid. No physical interaction of TKS and OAC. Polyketide cyclases may play a role in generating plant chemical diversity
physiological function
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polyketide synthases play an important role in the biosynthesis of secondary metabolites such as resveratrol, a candidate for cancer chemoprevention and naringenin, the precursor for flavonoids. Olivetolic acid is also be expected to be synthesized by a PKS
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