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Literature summary for 2.3.1.206 extracted from

  • Raharjo, T.; Chang, W.; Choi, Y.; Peltenburg-Looman, A.; Verpoorte, R.
    Olivetol as product of a polyketide synthase in Cannabis sativa L (2004), Plant Sci., 166, 381-385.
    View publication on PubMed
Search for more literature for 2.3.1.206

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 malonyl-CoA + hexanoyl-CoA Cannabis sativa
-
 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 formation of olivetol via C12-polyketide, no formation of olivetolic acid, product identification by its UV-spectrum, mass spectrometry analysis and comparison with reference compound ?

Organism

Organism UniProt Comment Textmining
Cannabis sativa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
 Cannabis sativa
-
inflorescence very high levels of cannabinoids in the flower tops Cannabis sativa
-
leaf upper Cannabis sativa
-
additional information no activity in seeds, roots, stems, and lower leaves Cannabis sativa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 malonyl-CoA + hexanoyl-CoA
-
 Cannabis sativa 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 formation of olivetol via C12-polyketide, no formation of olivetolic acid, product identification by its UV-spectrum, mass spectrometry analysis and comparison with reference compound ?
3 malonyl-CoA + hexanoyl-CoA
-
 Cannabis sativa 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 formation of olivetol via C12-polyketide by condensation and cyclization reactions, stilbene synthase like mechanism, overview. No formation of olivetolic acid, UV-spectrum and mass spectrometry analysis ?

Synonyms

Synonyms Comment Organism
PKS
-
 Cannabis sativa
polyketide synthase
-
 Cannabis sativa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Cannabis sativa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Cannabis sativa

General Information

General Information Comment Organism
metabolism the polyketide synthase catalyzes the first step of cannabinoid biosynthesis, leading to olivetolic acid Cannabis sativa
physiological function olivetolic acid is the first intermediate involved in the cannabinoid biosynthesis in Cannabis sativa leading to the acidic forms of the major cannabinoids such as DELTA9-tetrahydrocannabinolic acid and cannabinolic acid Cannabis sativa