2.3.1.161: lovastatin nonaketide synthase
This is an abbreviated version!
For detailed information about lovastatin nonaketide synthase, go to the full flat file.
Word Map on EC 2.3.1.161
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2.3.1.161
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polyketide
-
iterative
-
synthases
-
terreus
-
medicine
-
enoyl
-
megasynthase
-
cholesterol-lowering
-
s-adenosylmethionine
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diketide
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2-methylbutyrate
-
pyrones
-
transesterase
- 2.3.1.161
- polyketide
-
iterative
- synthases
- terreus
- medicine
-
enoyl
-
megasynthase
-
cholesterol-lowering
- s-adenosylmethionine
-
diketide
- 2-methylbutyrate
- pyrones
-
transesterase
Reaction
9 malonyl-CoA + 11 NADPH + 10 H+ + + = + 9 CoA + 9 CO2 + 11 NADP+ + + 6 H2O
Synonyms
LNKS, lovastatin nonaketide synthase, LovB, synthase, lovastatin nonaketide
ECTree
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Cloned
Cloned on EC 2.3.1.161 - lovastatin nonaketide synthase
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minimal polyketide synthase domains of subunit LovB as standalone proteins
the entire lovB gene is inserted into pET21a+ to create pSMa33, the LovB KS-MAT didomain, MAT, ACP, ACP-CON and CON are each amplified from pSMa33 and cloned into pET28a+