Literature summary for 2.3.1.161 extracted from

Hutchinson, C.R.; Kennedy, J.; Park, C.; Kendrew, S.; Auclair, K.; Vederas, J.
Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases (2000), Antonie van Leeuwenhoek, 78, 287-295.

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Cloned(Commentary)

Cloned (Comment)	Organism
wild type and different lov mutants	Aspergillus terreus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
335000	-	calculated from amino acid sequence	Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+	Aspergillus terreus	reaction mechanism, enzyme interacts with LovC to catalyze 35 separate reactions in the biosynthesis of dihydrononacolin	dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus terreus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+	enzyme contains six active sites: ketosynthase, acyltransferase, dehydratase, enoyl reductase, ketoreductase and acyl carrier protein	Aspergillus terreus	dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O	-	?
acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+	enzyme also displays Diels-Alderase activity in vitro	Aspergillus terreus	dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O	-	?
acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+	reaction mechanism, enzyme interacts with LovC to catalyze 35 separate reactions in the biosynthesis of dihydrononacolin	Aspergillus terreus	dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O	-	?

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Release 2023.1 (January 2023)