2.3.1.161: lovastatin nonaketide synthase

This is an abbreviated version!
For detailed information about lovastatin nonaketide synthase, go to the full flat file.

Reaction

9 malonyl-CoA + 11 NADPH + 10 H+ +

Synonyms

LNKS, lovastatin nonaketide synthase, LovB, synthase, lovastatin nonaketide

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.161 lovastatin nonaketide synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
62	AA Sequence
3	Application
1	CAS Registry Number
6	Cloned(Commentary)
4	Cofactor
1	General Information
1	General Stability
3	kcat/KM [mM/s]
5	KM Value [mM]
1	Metals/Ions
7	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
13	Organism
4	Pathway
7	PDB ID
5	Protein Variants
4	Purification (Commentary)
2	Reaction
12	Reaction Type
11	Reference
1	Specific Activity [micromol/min/mg]
21	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Systematic Name on EC 2.3.1.161 - lovastatin nonaketide synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

acyl-CoA:malonyl-CoA C-acyltransferase (dihydromonacolin L acid-forming)

This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. The PKS catalyses many of the chain building reactions of EC 2.3.1.85, fatty-acid synthase system, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.