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2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate synthase, go to the full flat file.

Word Map on EC 2.2.1.7

Reaction

pyruvate
+
D-glyceraldehyde 3-phosphate
=
1-deoxy-D-xylulose 5-phosphate
+
CO2

Synonyms

1-D-deoxy-D-threo-2-pentulose 5-phosphate synthetase, 1-D-deoxyxylulose 5-phosphate synthase, 1-deoxy-D-threo-pentulose synthase, 1-deoxy-D-xylulose 5-phosphate synthase, 1-deoxy-D-xylulose 5-phosphate synthase 1, 1-deoxy-D-xylulose 5-phosphate synthase 2, 1-deoxy-D-xylulose 5-phosphate synthetase, 1-deoxy-D-xylulose-5-phosphate pyruvate lyase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxy-D-xylulose-5-phosphate synthetase, 1-desoxy-D-xylulose-5-phosphate synthase, CSDXS, D-1-deoxyxylulose 5-phosphate synthase, deoxyxylulose 5-phosphate synthase, deoxyxylulose-5-phosphate synthase, deoxyxylulose-5-phosphate synthetase, DXP, DXP synthase, DXP-synthase, DXPase, DXPS, DXS, DXS-I, DXS-II, DXS1, dxs11, DXS2, DXS3, EC 4.1.3.37, GbDXS1, GbDXS2, glyceraldehydes 3-phosphate-pyruvate ligase, GmDXS1, MtDXS1, MtDXS2, OsDXS1, OsDXS2, OsDXS3, PaDXS1, PaDXS2A, PaDXS2B, PdDXS1, PdDXS2, synthase, 1-deoxy-D-xylulose 5-phosphate

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase

Crystallization

Crystallization on EC 2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
enzyme bound to C2alpha-phosphonolactyl-thiamine diphosphate and a native post-decarboxylation state with a bound enamine intermediate
-
purified recombinant wild-type and selenomethionine-labeled enzyme in complex with cofactor thiamine diphosphate, mixing of protein solution with reservoir solution containing 150 mM NaCl, and 20% w/v PEG 6000 or PEG 8000, cryoprotection by 25% v/v ethylene glycol, X-ray diffraction structure determination and analysis at 2.9 A resolution
-
purified recombinant wild-type and selenomethionine-labeled enzyme in complex with cofactor thiamine diphosphate, protein solution is mixed with the reservoir solution containing 30% w/v PEG 3350 and 200 mM Na,K-tartrate and infected by a fungus, the enzyme crystallized only after in situ proteolysis by a fungal protease, cryoprotection by 25% v/v ethylene glycol, X-ray diffraction structure determination and analysis at 2.4 A resolution
-