Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate synthase, go to the full flat file.

Word Map on EC 2.2.1.7

Reaction

pyruvate
+
D-glyceraldehyde 3-phosphate
=
1-deoxy-D-xylulose 5-phosphate
 +
CO2

Synonyms

1-D-deoxy-D-threo-2-pentulose 5-phosphate synthetase, 1-D-deoxyxylulose 5-phosphate synthase, 1-deoxy-D-threo-pentulose synthase, 1-deoxy-D-xylulose 5-phosphate synthase, 1-deoxy-D-xylulose 5-phosphate synthase 1, 1-deoxy-D-xylulose 5-phosphate synthase 2, 1-deoxy-D-xylulose 5-phosphate synthetase, 1-deoxy-D-xylulose-5-phosphate pyruvate lyase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxy-D-xylulose-5-phosphate synthetase, 1-desoxy-D-xylulose-5-phosphate synthase, CSDXS, D-1-deoxyxylulose 5-phosphate synthase, deoxyxylulose 5-phosphate synthase, deoxyxylulose-5-phosphate synthase, deoxyxylulose-5-phosphate synthetase, DXP, DXP synthase, DXP-synthase, DXPase, DXPS, DXS, DXS-I, DXS-II, DXS1, dxs11, DXS2, DXS3, EC 4.1.3.37, GbDXS1, GbDXS2, glyceraldehydes 3-phosphate-pyruvate ligase, GmDXS1, MtDXS1, MtDXS2, OsDXS1, OsDXS2, OsDXS3, PaDXS1, PaDXS2A, PaDXS2B, PdDXS1, PdDXS2, synthase, 1-deoxy-D-xylulose 5-phosphate

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase

IC50 Value

IC50 Value on EC 2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.291
1-methyl-2-nitrosobenzene
Escherichia coli
at pH 8.0 and 37°C
1.065
1-nitrosonaphthalen-2-ol
Escherichia coli
at pH 8.0 and 37°C
0.0719
2-methyl-3,5-diphenyl-6-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0306
2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0195
2-methyl-5-naphthalen-2-yl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0424
3,5-bis(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
2
3,5-dimethyl-4-nitroso-1-(propan-2-yl)-1H-pyrazole
Escherichia coli
IC50 above 2.0 mM, at pH 8.0 and 37°C
0.023
3,5-diphenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0535
3-(4-bromophenyl)-5-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.2
3-(4-bromophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
value above
0.0197
3-(4-chlorophenyl)-2-ethyl-5-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0342
3-(4-chlorophenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0551
3-(4-chlorophenyl)-2-methyl-5-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0109
3-(4-chlorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.2
3-(4-chlorophenyl)-5-(methoxymethyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
value above
0.2
3-(4-chlorophenyl)-5-(methoxymethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
value above
0.0984
3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.2
3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
value above
0.0411
3-(4-chlorophenyl)-5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0106
3-(4-fluorophenyl)-5-(4-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0907
3-(4-methoxyphenyl)-2-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0202 - 0.2
3-(4-methoxyphenyl)-5-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.2
5-(chloromethyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
value above
0.014
5-benzyl-3-(4-chlorophenyl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.1141
5-benzyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0711
5-benzyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.0637
5-[[(4-chlorophenyl)sulfanyl]methyl]-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
-
0.2
6-benzyl-3-(4-chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Mycobacterium tuberculosis
-
value above
0.522
6-bromo-1-nitrosonaphthalen-2-ol
Escherichia coli
at pH 8.0 and 37°C
0.354
6-hydroxy-5-nitrosonaphthalene-2-sulfonamide
Escherichia coli
at pH 8.0 and 37°C
2
7-methoxy-1-nitrosonaphthalen-2-ol
Escherichia coli
IC50 above 2.0 mM, at pH 8.0 and 37°C
0.2
ethyl (5-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)acetate
Mycobacterium tuberculosis
-
value above
0.073
methyl [3-(4-bromophenyl)-7-oxo-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl]acetate
Mycobacterium tuberculosis
-
-
0.0018 - 10
Methylacetylphosphonate
0.844
N,N-dimethyl-4-nitrosoaniline
Escherichia coli
at pH 8.0 and 37°C
0.208
nitrosobenzene
Escherichia coli
at pH 8.0 and 37°C