2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate synthase, go to the full flat file.

Reaction

Synonyms

1-D-deoxy-D-threo-2-pentulose 5-phosphate synthetase, 1-D-deoxyxylulose 5-phosphate synthase, 1-deoxy-D-threo-pentulose synthase, 1-deoxy-D-xylulose 5-phosphate synthase, 1-deoxy-D-xylulose 5-phosphate synthase 1, 1-deoxy-D-xylulose 5-phosphate synthase 2, 1-deoxy-D-xylulose 5-phosphate synthetase, 1-deoxy-D-xylulose-5-phosphate pyruvate lyase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxy-D-xylulose-5-phosphate synthetase, 1-desoxy-D-xylulose-5-phosphate synthase, CSDXS, D-1-deoxyxylulose 5-phosphate synthase, deoxyxylulose 5-phosphate synthase, deoxyxylulose-5-phosphate synthase, deoxyxylulose-5-phosphate synthetase, DXP, DXP synthase, DXP-synthase, DXPase, DXPS, DXS, DXS-I, DXS-II, DXS1, dxs11, DXS2, DXS3, EC 4.1.3.37, GbDXS1, GbDXS2, glyceraldehydes 3-phosphate-pyruvate ligase, GmDXS1, MtDXS1, MtDXS2, OsDXS1, OsDXS2, OsDXS3, PaDXS1, PaDXS2A, PaDXS2B, PdDXS1, PdDXS2, synthase, 1-deoxy-D-xylulose 5-phosphate

ECTree

     2 Transferases

         2.2 Transferring aldehyde or ketonic groups

             2.2.1 Transketolases and transaldolases

                2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase

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Results	in table
3	Activating Compound
42134	AA Sequence
11	Application
1	CAS Registry Number
49	Cloned(Commentary)
29	Cofactor
3	Crystallization (Commentary)
14	Expression
23	General Information
48	IC50 Value
118	Inhibitors
64	kcat/KM [mM/s]
72	Ki Value [mM]
109	KM Value [mM]
20	Localization
22	Metals/Ions
33	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
135	Organism
13	Pathway
21	PDB ID
12	pH Optimum
1	pH Range
13	pI Value
2	Posttranslational Modification
45	Protein Variants
17	Purification (Commentary)
5	Reaction
2	Reaction Type
91	Reference
89	Source Tissue
6	Specific Activity [micromol/min/mg]
2	Storage Stability
114	Substrates and Products (Substrate)
30	Subunits
158	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
67	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

pyruvate + D-glyceraldehyde

1-deoxy-D-xylulose + CO2

Escherichia coli

-

the reaction product, 1-deoxy-D-xylulose 5-phosphate, is a precursor to isoprenoids and vitamins

659734

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

41 entries

additional information

?

-

2 entries

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Agrobacterium tumefaciens

Q5QKF8

-

674982

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Agrobacterium tumefaciens KCCM 10413

-

-

674982

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Aquilaria sinensis

-

-

737021

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Arabidopsis thaliana

Q38854

-

676623

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Arabidopsis thaliana

-

plastidic isoprenoid synthesis in plants, catalyses one of the rate-limiting steps

395817

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Citrus clementina

-

the enzyme expression is decreased during degreening and natural color break, which is delayed by gibberellin and nitrate, 2C-methyl-D-erythritol-4-phosphate, MEP, pathway and regulation, as part of the plastidial isoprenoid pathway, overview

674123

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Deinococcus radiodurans

-

-

736085, 757220

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Deinococcus radiodurans

Q9RUB5

-

756018, 757477

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Deinococcus radiodurans

-

the enzyme is crucial in the isoprenoid pathway, catalyzing the first step of the 2C-methyl-D-erythritol-4-phosphate, MEP, DXS is also a crucial enzyme for the biosynthesis of isopentenyl diphosphate, thiamine, and pyridoxol

674856

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Deinococcus radiodurans DSM 20539

Q9RUB5

-

756018, 757477

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Dendrobium officinale

W0FI66

-

757994

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Elaeis guineensis

Q6IZE6, Q6PRU5

the enzyme is involved in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway performing the initial step

676663

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli

-

-

735949, 755692, 756052, 756065

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli

P77488

-

735946, 758230

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli

-

-

758230

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli

P77488

-

758287

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli

P77735

-

735503

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli

-

the enzyme is crucial in the isoprenoid pathway, catalyzing the first step of the 2C-methyl-D-erythritol-4-phosphate, MEP, DXS is also a crucial enzyme for the biosynthesis of isopentenyl diphosphate, thiamine, and pyridoxol

674856

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli

-

the enzyme is important in the plastidic pathway of isoprenoid biosynthesis, including the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway, in plants and shows a regulatory role catalyzing the initial step, overview

675139

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli MG1655

-

-

755692

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Escherichia coli MG1655

P77735

-

735503

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Ginkgo biloba

Q5J5B3

the enzyme catalyzes the first committed step in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway which leads to the biosynthesis of gingkolides, in which the enzyme expression level might play a regulatory role

676738

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Ginkgo biloba

Q5J7B4

the enzyme catalyzes the first committed step in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway which leads to the biosynthesis of gingkolides, overview, gingkolides are synthesized in roots and then translocated to the leaves

676736

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Lavandula latifolia

-

-

736693

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Lavandula latifolia

-

the enzyme is involved in the plastidial 2C-methyl-D-erythritol-4-phosphate, MEP, pathway and plays a crucial role in monoterpene precursor biosynthesis for the production of essential oils in leaves and flowers, overview

676623

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Medicago truncatula

-

potential importance of DXS1 in many housekeeping functions, hypothetical role of DXS2 in the biosynthesis of secondary isoprenoids

660165

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Morinda citrifolia

-

the enzyme catalyzes the first step of the methyl-D-erythritol 4-phosphate pathway. Antraquinone biosynthesis is regulated at the transcriptional level of the DXS gene

660277

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Nicotiana tabacum

D2CS41

-

736967

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Oryza sativa

-

the enzyme catalyzes the first step in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway, with differential expression of genes dxs1, dxs2, and dxs3, overview

672737

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Pinus kesiya var. langbianensis

-

-

756215

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Plasmodium falciparum

-

-

737194

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Plasmodium falciparum

Q8IDW0

-

756514

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Plasmodium vivax

-

-

737194

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Plasmodium vivax

A5K817

-

719510

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Populus trichocarpa

-

-

736415

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Salvia miltiorrhiza

B4YSH1, C4NXC0

-

757643

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Solanum lycopersicum

C7U110

-

758411

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Solanum tuberosum

E7CCH1

-

737046

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Synechocystis sp.

P73067

-

736523

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Synechocystis sp. PCC 6803

-

-

757263

-

-

?

pyruvate + D-glyceraldehyde 3-phosphate

1-deoxy-D-xylulose 5-phosphate + CO2

Taxus chinensis

-

-

756492

-

-

?

additional information

?

-

Ginkgo biloba

Q5J7B4

gingkolides are diterpenoids and potent platelet-activating factor antagonists

676736

-

-

?

additional information

?

-

Ginkgo biloba

-

gingkolides are diterpenoids and potent platelet-activating factor antagonists

676736

-

-

?