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2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate synthase, go to the full flat file.

Word Map on EC 2.2.1.7

Reaction

pyruvate
+
D-glyceraldehyde 3-phosphate
=
1-deoxy-D-xylulose 5-phosphate
 +
CO2

Synonyms

1-D-deoxy-D-threo-2-pentulose 5-phosphate synthetase, 1-D-deoxyxylulose 5-phosphate synthase, 1-deoxy-D-threo-pentulose synthase, 1-deoxy-D-xylulose 5-phosphate synthase, 1-deoxy-D-xylulose 5-phosphate synthase 1, 1-deoxy-D-xylulose 5-phosphate synthase 2, 1-deoxy-D-xylulose 5-phosphate synthetase, 1-deoxy-D-xylulose-5-phosphate pyruvate lyase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxy-D-xylulose-5-phosphate synthetase, 1-desoxy-D-xylulose-5-phosphate synthase, CSDXS, D-1-deoxyxylulose 5-phosphate synthase, deoxyxylulose 5-phosphate synthase, deoxyxylulose-5-phosphate synthase, deoxyxylulose-5-phosphate synthetase, DXP, DXP synthase, DXP-synthase, DXPase, DXPS, DXS, DXS-I, DXS-II, DXS1, dxs11, DXS2, DXS3, EC 4.1.3.37, GbDXS1, GbDXS2, glyceraldehydes 3-phosphate-pyruvate ligase, GmDXS1, MtDXS1, MtDXS2, OsDXS1, OsDXS2, OsDXS3, PaDXS1, PaDXS2A, PaDXS2B, PdDXS1, PdDXS2, synthase, 1-deoxy-D-xylulose 5-phosphate

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase

KI Value

KI Value on EC 2.2.1.7 - 1-deoxy-D-xylulose-5-phosphate synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.001
(1E,1'E)-O,O'-(ethane-1,2-diyl)bis[2,4,5-trihydroxybenzaldehyde oxime]
-
at pH 8.0 and 37°C
0.0184
(1E,7E)-1-(2,4,5-trihydroxyphenyl)-3,6-dioxa-2,7-diazanona-1,7-dien-9-oate
-
at pH 8.0 and 37°C
0.00033
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate
-
at pH 8.0 and 37°C
0.00009
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate
-
at pH 8.0 and 37°C
0.0029
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate
-
at pH 8.0 and 37°C
0.001
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate
-
at pH 8.0 and 37°C
0.0021
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate
-
at pH 8.0 and 37°C
0.0013
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate
-
at pH 8.0 and 37°C
0.0091
(E)-2,4,5-trihydroxybenzaldehyde O-benzyl oxime
-
at pH 8.0 and 37°C
0.0039
(E)-2,4,5-trihydroxybenzaldehyde O-methyl oxime
-
at pH 8.0 and 37°C
0.0026
(E)-2,4,5-trihydroxybenzaldehyde oxime
-
at pH 8.0 and 37°C
0.2
(E)-2,4-dihydroxybenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.2
(E)-2,5-dihydroxybenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.0151
(E)-2-fluoro-4,5-dihydroxybenzaldehyde O-methyl oxime
-
at pH 8.0 and 37°C
0.2
(E)-2-fluoro-4,5-dimethoxybenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.0478
(E)-2-hydroxy-3-nitrobenzaldehyde O-methyl oxime
-
at pH 8.0 and 37°C
0.2
(E)-2-hydroxybenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.0294
(E)-3,4,5-trihydroxybenzaldehyde O-methyl oxime
-
at pH 8.0 and 37°C
0.2
(E)-3,4-dihydroxy-5-methoxybenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.2
(E)-4,5-difluoro-2-hydroxybenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.2
(E)-4-hydroxy-3-nitrobenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.075
(E)-5-[(2-methylhydrazono)methyl]benzene-1,2,4-triol
-
Ki above 0.075 mM, at pH 8.0 and 37°C
0.2
(E)-uracil-6-carbaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.1
(E,Z)-2,4,5-trimethoxybenzaldehyde O-methyl oxime
-
Ki above 0.1 mM, at pH 8.0 and 37°C
0.2
(E,Z)-3,4-dihydroxybenzaldehyde O-methyl oxime
-
Ki above 0.2 mM, at pH 8.0 and 37°C
0.13 - 0.83
1-deoxy-D-xylulose 5-phosphate
0.008
2-(1-benzyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00044
2-(1-cyclohexyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.003
2-(1-pentyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00083
2-(1-[(2S)-1-[methyl(4-methylbenzene-1-sulfonyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00052
2-(1-[2-[methyl(methylsulfonyl)amino]-2-oxoethyl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.001
2-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00011
2-[1-(2-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.0013
2-[1-(2-methoxy-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.0054
2-[1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.008
2-[1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00047
2-[1-(2-[methyl[(4-methylphenyl)sulfonyl]amino]-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00032
2-[1-(3-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.006
2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.0027
2-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00084
2-[1-(carboxymethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.006
2-[1-(prop-2-en-1-yl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.008
2-[1-[4-(methoxycarbonyl)benzyl]-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.035 - 0.043
3-fluoro-2-oxopropanoate
0.2
3-Fluoropyruvate
pH and temperature not specified in the publication
0.075
5-[(methoxyamino)methyl]benzene-1,2,4-triol
-
Ki above 0.075 mM, at pH 8.0 and 37°C
0.0104
benzylacetylphosphonate
at pH 8.0 and 37°C
0.0033 - 0.057
beta-fluoropyruvate
0.0056
butyl acetyl phosphonate
-
at pH 8.0 and 37°C
0.0026 - 0.0056
butylacetylphosphonate
3.2
D-glyceraldehyde
-
pH 8.0, 37°C
0.0813
dimethylallyl diphosphate
-
at pH 8.0 and 37°C
0.00671
ethyl acetylphosphonate
-
at pH 8.0 and 37°C
0.0089
hexyl acetylphosphonate
-
at pH 8.0 and 37°C
0.0654
isopentenyl diphosphate
-
at pH 8.0 and 37°C
0.075
ketoclomazone
-
at pH 8.0 and 37°C
0.00047
lithium but-3-yn-1-yl acetylphosphonate
-
at pH 8.0 and 37°C
0.001
methyl acetylphosphonate
-
at pH 8.0 and 37°C
0.00324 - 1.08
Methylacetylphosphonate
0.0014
octyl acetylphosphonate
-
at pH 8.0 and 37°C
0.0017
pentyl acetylphosphonate
-
at pH 8.0 and 37°C
0.0071
propyl acetylphosphonate
-
at pH 8.0 and 37°C