2.1.2.11: 3-methyl-2-oxobutanoate hydroxymethyltransferase
This is an abbreviated version!
For detailed information about 3-methyl-2-oxobutanoate hydroxymethyltransferase, go to the full flat file.
Word Map on EC 2.1.2.11
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2.1.2.11
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pantothen
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auxotrophs
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aldol
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l-valine
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beta-alanine
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pane
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betaalpha8
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2-oxoacids
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pharmacology
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alpha-ketobutyrate
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decameric
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4'-phosphopantetheine
- 2.1.2.11
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pantothen
-
auxotrophs
-
aldol
- l-valine
- beta-alanine
-
pane
-
betaalpha8
- 2-oxoacids
- pharmacology
- alpha-ketobutyrate
-
decameric
- 4'-phosphopantetheine
Reaction
Synonyms
5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase, alpha-ketoisovalerate hydroxymethyltransferase, dehydropantoate hydroxymethyltransferase, hydroxymethyltransferase, ketopantoate, ketopantoate hydroxymethyl transferase, ketopantoate hydroxymethyltransferase, KHMT, KPHMT, MOHMT, oxopantoate hydroxymethyltransferase, PanB
ECTree
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General Information
General Information on EC 2.1.2.11 - 3-methyl-2-oxobutanoate hydroxymethyltransferase
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evolution
metabolism
additional information
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phylogenetic analysis of rhizobial panCB genes indicates a common origin of chromosomal and plasmid-borne sequences. Gene pan B in Rhizobiales with multipartite genomes, overview
evolution
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phylogenetic analysis of rhizobial panCB genes indicates a common origin of chromosomal and plasmid-borne sequences. Gene pan B in Rhizobiales with multipartite genomes, overview
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the enzyme is the first enzyme of the pantothenate biosynthesis pathway, responsible for the formation of 2-oxopantoate by the transfer of a methyl group from 5,10-methylentetrahydrofolate to 2-oxoisovalerate
metabolism
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enzyme overexpression leads to accumulation of the likely folate cleavage product 6-hydroxymethylpterin and other pterins in cells and medium, and to a 46% increase in total folate content
metabolism
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the enzyme is involved in D-pantothenic acid biosynthesis
metabolism
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the enzyme is the first enzyme of the pantothenate biosynthesis pathway, responsible for the formation of 2-oxopantoate by the transfer of a methyl group from 5,10-methylentetrahydrofolate to 2-oxoisovalerate
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metabolism
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the enzyme is involved in D-pantothenic acid biosynthesis
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metabolism
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enzyme overexpression leads to accumulation of the likely folate cleavage product 6-hydroxymethylpterin and other pterins in cells and medium, and to a 46% increase in total folate content
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the putative MOHMT encoded by RHE_PE00443 is not functional under the conditions studied and provides evidence of functional cooperation between p42f and chromosomally encoded proteins for pantothenate biosynthesis
additional information
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the putative MOHMT encoded by RHE_PE00443 is not functional under the conditions studied and provides evidence of functional cooperation between p42f and chromosomally encoded proteins for pantothenate biosynthesis
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