2.1.1.57: methyltransferase cap1

This is an abbreviated version!
For detailed information about methyltransferase cap1, go to the full flat file.

Word Map on EC 2.1.1.57

2.1.1.57

sars-cov-2

coronaviruses

2'-o-methylation

non-structural

flaviviruses

sinefungin

coronaviridae

2'-o-ribose

adomet-dependent

nsp8

n7-mtase

3clpro

replication-transcription

guanine-n7

guanine-n7-methyltransferase

analysis

medicine

Reaction

a 5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA]

a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]

Synonyms

(nucleoside-2'-O-)-methyltransferase, (nucleoside-2'O)-methyltransferase, 2'-O methyltransferase, 2'-O MTase, 2'-O-methyltransferase, 2'-O-MTase, 2'O methyltransferase, 2'O-MTase, 2'OMTases, cap-specific 2'-O-methyltransferase, cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, cap1 2-O'-ribose methyltransferase, CMTr1, EC 2.1.1.58, FtsJ methyltransferase domain-containing 2, FTSJD2, ISG95, KIAA0082, L protein domain VI, large polymerase protein domain VI, messenger ribonucleate nucleoside 2'-methyltransferase, messenger RNA (nucleoside-2'-)-methyltransferase, methyltransferase, messenger ribonucleate nucleoside 2'-, mRNA (nucleoside-2'-O)-methyltransferase, mRNA 5' cap-specific (nucleoside-2'-O)-methyltransferase, mRNA cap (nucleoside-2'-O)-methyltransferase, mRNA cap methyltransferase, mRNA cap-specific 2'-O-methyltransferase, MT57, Mtr1, nonstructural protein 16, nonstructural protein 16 methyltransferase, nonstructural protein 5 methyltransferase, NS5, NS5 MTase, NS5MTase, nsp10/16 complex, nsp10/nsp16 complex, nsp16, nsp16 protein, nsp16/nsp10 protein complex, ribose 2'-O methyltransferase, RNA (nucleoside-2'O)-methyltransferase, RNA cap 2'-O-methyltransferase, RNA cap 2'-O-MTase, RNA cap 2'O-MTase, RNA cap1 methyltransferase, RNA capping enzyme domain in protein A, S-adenosyl-L-methionine-dependent mRNA cap MTase, TbMT48, TbMT57, VP39, VP4

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.57 methyltransferase cap1

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Results	in table
13	Activating Compound
2719	AA Sequence
7	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
143	Disease/ Diagnostics
3	General Information
2	General Stability
5	IC50 Value
49	Inhibitors
15	Ki Value [mM]
12	KM Value [mM]
13	Localization
6	Metals/Ions
11	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
97	Organism
1	Pathway
164	PDB ID
9	pH Optimum
5	pH Range
3	pH Stability
111	Protein Variants
20	Purification (Commentary)
6	Reaction
1	Reaction Type
42	Reference
5	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
83	Substrates and Products (Substrate)
8	Subunits
81	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
4	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 2.1.1.57 - methyltransferase cap1

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3'-deoxy-ribavirin 5'-triphosphate

Dengue virus

P12823

binds almost as efficiently as ribavirin 5-triphosphate

662252

5',N8-Adenosyl-alpha,beta-diaminobutyric acid