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2.1.1.57: methyltransferase cap1

This is an abbreviated version!
For detailed information about methyltransferase cap1, go to the full flat file.

Word Map on EC 2.1.1.57

Reaction

S-adenosyl-L-methionine
+
a 5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA]
=
S-adenosyl-L-homocysteine
 +
a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]

Synonyms

(nucleoside-2'-O-)-methyltransferase, (nucleoside-2'O)-methyltransferase, 2'-O methyltransferase, 2'-O MTase, 2'-O-methyltransferase, 2'-O-MTase, 2'O methyltransferase, 2'O-MTase, 2'OMTases, cap-specific 2'-O-methyltransferase, cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, cap1 2-O'-ribose methyltransferase, CMTr1, EC 2.1.1.58, FtsJ methyltransferase domain-containing 2, FTSJD2, ISG95, KIAA0082, L protein domain VI, large polymerase protein domain VI, messenger ribonucleate nucleoside 2'-methyltransferase, messenger RNA (nucleoside-2'-)-methyltransferase, methyltransferase, messenger ribonucleate nucleoside 2'-, mRNA (nucleoside-2'-O)-methyltransferase, mRNA 5' cap-specific (nucleoside-2'-O)-methyltransferase, mRNA cap (nucleoside-2'-O)-methyltransferase, mRNA cap methyltransferase, mRNA cap-specific 2'-O-methyltransferase, MT57, Mtr1, nonstructural protein 16, nonstructural protein 16 methyltransferase, nonstructural protein 5 methyltransferase, NS5, NS5 MTase, NS5MTase, nsp10/16 complex, nsp10/nsp16 complex, nsp16, nsp16 protein, nsp16/nsp10 protein complex, ribose 2'-O methyltransferase, RNA (nucleoside-2'O)-methyltransferase, RNA cap 2'-O-methyltransferase, RNA cap 2'-O-MTase, RNA cap 2'O-MTase, RNA cap1 methyltransferase, RNA capping enzyme domain in protein A, S-adenosyl-L-methionine-dependent mRNA cap MTase, TbMT48, TbMT57, VP39, VP4

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.57 methyltransferase cap1

Substrates Products

Substrates Products on EC 2.1.1.57 - methyltransferase cap1

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 7Me-GpppA-C5
S-adenosyl-L-homocysteine + 7Me-GpppA-2'OMe-C5
show the reaction diagram
S-adenosyl-L-methionine + 7Me-GpppA-Cn
S-adenosyl-L-homocysteine + 7Me-GpppA-2'OMe-Cn
show the reaction diagram
-
exclusive methylation at the 2'O position
-
-
?
S-adenosyl-L-methionine + 7Me-GpppG
S-adenosyl-L-homocysteine + 7Me-Gppp-2'OMe-G
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA]
S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA]
show the reaction diagram
S-adenosyl-L-methionine + ApppGR-RNA
?
show the reaction diagram
S-adenosyl-L-methionine + brome mosaic virus RNA
?
show the reaction diagram
-
-
-
-
r
S-adenosyl-L-methionine + G(5')pppA-poly(A)
S-adenosyl-L-homocysteine + G(5')pppA-2'-OMe-poly(A)
show the reaction diagram
-
-
-
-
r
S-adenosyl-L-methionine + GpppA-Cn
S-adenosyl-L-homocysteine + GpppA-2'OMe-Cn
show the reaction diagram
-
exclusive methylation at the 2'O position
-
-
?
S-adenosyl-L-methionine + GpppACCCCC
S-adenosyl-L-homocysteine + GpppAmCCCCC
show the reaction diagram
-
-
?
S-adenosyl-L-methionine + m7G(5')pppA-poly(A)
S-adenosyl-L-homocysteine + m7G(5')pppA-2'-OMe-poly(A)
show the reaction diagram
-
-
-
-
r
S-adenosyl-L-methionine + m7G(5')pppA-RNA
S-adenosyl-L-homocysteine + m7G(5')pppAm-RNA
show the reaction diagram
S-adenosyl-L-methionine + m7G(5')pppA-RNA
S-adenosyl-L-homocysteine + m7G(5')pppRA-RNA
show the reaction diagram
S-adenosyl-L-methionine + m7G(5')pppG-RNA
S-adenosyl-L-homocysteine + m7G(5')pppGm-RNA
show the reaction diagram
S-adenosyl-L-methionine + m7G(5')pppN-RNA
S-adenosyl-L-homocysteine + m7G(5')pppNm-RNA
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m7G(5')pppNmpN-RNA
S-adenosyl-L-homocysteine + m7G(5')pppNmpNm-RNA
show the reaction diagram
-
N: purin and pyrimidine nucleotides are methylated, enzyme: cap II-methyltransferase
i.e. cap II
?
S-adenosyl-L-methionine + m7G(5')pppNpN-RNA
S-adenosyl-L-homocysteine + m7G(5')pppNmpN-RNA
show the reaction diagram
-
i.e. cap O, N: purine and pyrimidine nucleotides are methylated, enzyme: cap I-methyltransferase, substrates are RNAs with a capped terminus with at least 2 additional nucleotides, G(5')pppNpNp
i.e. cap I
?
S-adenosyl-L-methionine + m7G(5')pppR-RNA
S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA
show the reaction diagram
S-adenosyl-L-methionine + m7G-(5')pppGpApApA
?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + m7GpppACCCCC
S-adenosyl-L-homocysteine + m7GpppAmCCCCC
show the reaction diagram
-
-
?
S-adenosyl-L-methionine + m7GpppApGp
S-adenosyl-L-homocysteine + m7GpppAmpGp
show the reaction diagram
-
i.e. capped dinucleotide, cap I-methyltransferase
-
?
S-adenosyl-L-methionine + m7GpppApGpUp
S-adenosyl-L-homocysteine + m7GpppAmpGpUp
show the reaction diagram
-
i.e. capped trinucleotide, cap I-methyltransferase
-
?
S-adenosyl-L-methionine + m7GpppG
S-adenosyl-L-homocysteine + m7GpppGm
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + m7GpppGp
S-adenosyl-L-homocysteine + m7GpppGmp
show the reaction diagram
-
substrate of minimal chain length for the cap-specific enzyme, m7GpppG is no substrate
-
-
?
S-adenosyl-L-methionine + m7GpppGpN
S-adenosyl-L-homocysteine + m7GpppGmpN
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m7GpppGpNp
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + m7GpppGpUbiotin-p
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + mononucleotide
?
show the reaction diagram
-
such as m7GpppA or GpppA, poor substrates for cap I-methyltransferase
-
-
?
S-adenosyl-L-methionine + RNA chain length 2-6 nt
?
show the reaction diagram
-
-
-
-
r
S-adenosyl-L-methionine + RNA chain length 20-50 nt
?
show the reaction diagram
-
-
-
-
r
additional information
?
-