2.1.1.320: type II protein arginine methyltransferase

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For detailed information about type II protein arginine methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

At4g31120, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Hsl7, Jak-binding protein 1, Janus kinase-binding protein 1, JBP1, PRMT-5, PRMT-9, PRMT15, PRMT5, PRMT7, PRMT9, protein arginine methyltransferase 5, Skb1

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.320 type II protein arginine methyltransferase

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Results	in table
1	Activating Compound
5693	AA Sequence
4	Application
4	Cloned(Commentary)
5	Crystallization (Commentary)
1867	Disease/ Diagnostics
6	Expression
38	General Information
58	IC50 Value
59	Inhibitors
4	KM Value [mM]
19	Localization
6	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
48	Organism
58	PDB ID
4	Protein Variants
1	Purification (Commentary)
3	Reaction
48	Reference
54	Source Tissue
66	Substrates and Products (Substrate)
4	Subunits
53	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 2.1.1.320 - type II protein arginine methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)

The enzyme catalyses the methylation of one of the terminal guanidino nitrogen atoms in arginine residues within proteins, forming monomethylarginine, followed by the methylation of the second terminal nitrogen atom to form a symmetrical dimethylarginine. The mammalian enzyme is active in both the nucleus and the cytoplasm, and plays a role in the assembly of snRNP core particles by methylating certain small nuclear ribonucleoproteins. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.