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2.1.1.320: type II protein arginine methyltransferase

This is an abbreviated version!
For detailed information about type II protein arginine methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.320

Reaction

2 S-adenosyl-L-methionine +

[protein]-L-arginine
= 2 S-adenosyl-L-homocysteine +
[protein]-Nomega,Nomega'-dimethyl-L-arginine

Synonyms

At4g31120, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Hsl7, Jak-binding protein 1, Janus kinase-binding protein 1, JBP1, PRMT-5, PRMT-9, PRMT15, PRMT5, PRMT7, PRMT9, protein arginine methyltransferase 5, Skb1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.320 type II protein arginine methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.320 - type II protein arginine methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + [D2 dopamine receptor]-L-arginine
2 S-adenosyl-L-homocysteine + [D2 dopamine receptor]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
recombinant fragment of the third intracellular loop of D2, corresponding to amino acid residues 211 to 241 fused to glutathione S-transferase. Residues Arg217 and Arg219 are key methylation sites within this region
-
-
?
2 S-adenosyl-L-methionine + [DOP-3 receptor]-L-arginine
2 S-adenosyl-L-homocysteine + [DOP-3 receptor]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
recombinant fragment of the third intracellular loop of Caenorhabditis elegans DOP-3, amino acid residues 202 to 232 fused to GST. Residues Arg208 and Arg210 are key methylation sites within this region
-
-
?
2 S-adenosyl-L-methionine + [germ cell-specific protein Vasa]-L-arginine
2 S-adenosyl-L-homocysteine + [germ cell-specific protein Vasa]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [germ cell-specific protein Zili]-L-arginine
2 S-adenosyl-L-homocysteine + [germ cell-specific protein Zili]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [golgin GM130]-L-arginine
2 S-adenosyl-L-homocysteine + [golgin GM130]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
overall reaction
-
?
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [histone H3R8]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3R8]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [histone H3]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H3]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
isoform PRMT5 bound to nuclear protein COPR5 methylates histone histone H3 at residue R8. Methylation of histone H4 is preferred over histone H3
-
?
2 S-adenosyl-L-methionine + [histone H4 peptide]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H4 peptide]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
both PRMT5 alone and PRMT5 in complex with MEP50 are able to generate di-methylated H4 peptide product. The PRMT5:MEP50 complex consistently has a higher level of methyltransferase activity compared with PRMT5
-
?
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [histone H4]-L-arginine
2 S-adenosyl-L-homocysteine + [histone H4]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [KRAB-associated protein 1]-L-arginine
2 S-adenosyl-L-homocysteine + [KRAB-associated protein 1]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [protein]-L-arginine
2 S-adenosyl-L-homocysteine + [protein]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [SER-2 tyramine receptor]-L-arginine
2 S-adenosyl-L-homocysteine + [SER-2 tyramine receptor]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [SmD3 protein]-L-arginine
2 S-adenosyl-L-homocysteine + [SmD3 protein]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [splicing factor SF3B2]-L-arginine
2 S-adenosyl-L-homocysteine + [splicing factor SF3B2]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
2 S-adenosyl-L-methionine + [voltage-gated sodium channel NaV1.5]-L-arginine
2 S-adenosyl-L-homocysteine + [voltage-gated sodium channel NaV1.5]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [GST-fibrillarin]-L-arginine
S-adenosyl-L-homocysteine + [GST-fibrillarin]-Nomega-methyl-L-arginine
show the reaction diagram
substrate is amino terminus of fibrillarin fused to glutathione S-transferase
-
-
?
S-adenosyl-L-methionine + [GST-fibrillarin]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [GST-fibrillarin]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [GST-GAR]-L-arginine
S-adenosyl-L-homocysteine + [GST-GAR]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [GST-GAR]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [GST-GAR]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + [histone H2A]-L-arginine
S-adenosyl-L-homocysteine + [histone H2A]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [histone H2A]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [histone H2A]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [histone H4]-L-arginine
S-adenosyl-L-homocysteine + [histone H4]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone H4]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [histone H4]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone]-L-arginine
S-adenosyl-L-homocysteine + [histone]-Nomega-methyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [histone]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [histone]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + [myelin basic protein]-L-arginine
S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega-methyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [myelin basic protein]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [myelin basic protein]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
S-adenosyl-L-methionine + [nucleoplasmin]-L-arginine
S-adenosyl-L-homocysteine + [nucleoplasmin]-Nomega-methyl-L-arginine
show the reaction diagram
-
nucleoplasmin is a potent substrate and is monomethylated and symmetrically dimethylated at Arg187
-
?
S-adenosyl-L-methionine + [nucleoplasmin]-Nomega-methyl-L-arginine
S-adenosyl-L-homocysteine + [nucleoplasmin]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
-
nucleoplasmin is a potent substrate and is monomethylated and symmetrically dimethylated at Arg187
-
?
S-adenosyl-L-methionine + [splicing factor SF3B2]-L-arginine
S-adenosyl-L-homocysteine + [splicing factor SF3B2]-Nomega-methyl-L-arginine
show the reaction diagram
the enzyme methylates the R508 residue
-
-
?
S-adenosyl-L-methionine + [splicing factor SF3B2]-Nomega-L-arginine
S-adenosyl-L-homocysteine + [splicing factor SF3B2]-Nomega,Nomega'-dimethyl-L-arginine
show the reaction diagram
the enzyme methylates the R508 residue
-
-
?
additional information
?
-