2.1.1.320: type II protein arginine methyltransferase

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For detailed information about type II protein arginine methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

At4g31120, EC 2.1.1.124, EC 2.1.1.125, EC 2.1.1.126, EC 2.1.1.23, Hsl7, Jak-binding protein 1, Janus kinase-binding protein 1, JBP1, PRMT-5, PRMT-9, PRMT15, PRMT5, PRMT7, PRMT9, protein arginine methyltransferase 5, Skb1

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.320 type II protein arginine methyltransferase

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Results	in table
1	Activating Compound
5693	AA Sequence
4	Application
4	Cloned(Commentary)
5	Crystallization (Commentary)
1867	Disease/ Diagnostics
6	Expression
38	General Information
58	IC50 Value
59	Inhibitors
4	KM Value [mM]
19	Localization
6	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
48	Organism
58	PDB ID
4	Protein Variants
1	Purification (Commentary)
3	Reaction
48	Reference
54	Source Tissue
66	Substrates and Products (Substrate)
4	Subunits
53	Synonyms
1	Systematic Name

KM Value

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KM Value on EC 2.1.1.320 - type II protein arginine methyltransferase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000022 - 0.001

S-adenosyl-L-methionine

2 entries

0.0042 - 0.0102

[histone H4 peptide]-L-arginine

2 entries

-

0.000022

S-adenosyl-L-methionine

Homo sapiens

O14744

isoform PRMT5, presence of 0.001 mM histone H4 peptide, 22°C, pH not specified in the publication

735162

0.001

S-adenosyl-L-methionine

Homo sapiens

O14744

isoform PRMT5 in complex with MEP50, presence of 0.001 mM histone H4 peptide, 22°C, pH not specified in the publication

735162

0.0042

[histone H4 peptide]-L-arginine

Homo sapiens

O14744

isoform PRMT5, presence of 0.01 mM S-adenosyl-L-methionine, 22°C, pH not specified in the publication

735162

-

0.0102

[histone H4 peptide]-L-arginine

Homo sapiens

O14744

isoform PRMT5 in complex with MEP50,presence of 0.01 mM S-adenosyl-L-methionine, 22°C, pH not specified in the publication

735162

-