2.1.1.249: dimethylamine-corrinoid protein Co-methyltransferase

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For detailed information about dimethylamine-corrinoid protein Co-methyltransferase, go to the full flat file.

Reaction

a [Co(I) dimethylamine-specific corrinoid protein]

a [methyl-Co(III) dimethylamine-specific corrinoid protein]

Synonyms

dimethyl-12-HBI methyltransferase, dimethylamine methyltransferase, dimethylamine/5-hydroxybenzimidazolylcobamide methyltransferase, dimethylamine: corrinoid methyltransferase, dimethylamine:CoM methyltransferase, dimethylamine:corrinoid methyltransferase, DMA methyltransferase, DMA-MT, DMA:CoM methyltransferase, DMA:corrinoid methyltransferase, MtbB, MtbB1, MtbB2, MtbB3, MtcB

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.249 dimethylamine-corrinoid protein Co-methyltransferase

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Results	in table
7	Activating Compound
277	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
2	Cofactor
16	General Information
2	Inhibitors
1	Ki Value [mM]
3	Metals/Ions
8	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
27	Organism
3	Pathway
3	pH Optimum
1	pI Value
5	Purification (Commentary)
3	Reaction
15	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
8	Subunits
34	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.249 - dimethylamine-corrinoid protein Co-methyltransferase

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dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein]

a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine

7 entries

dimethylamine + a [Co(I) methylamine-specific corrinoid protein]

a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine

2 entries

additional information

Methanosarcina barkeri

MtbB1 demethylates dimethylamine and specifically methylates the corrinoid prosthetic group of MtbC, which is subsequently demethylated by MtbA to methylate coenzyme M during methanogenesis from dimethylamine. A MtbB1to corrinoid protein MtbC ratio of 1 is optimal for coenzyme M methylation with dimethylamine. MtbB1 methylated either corrinoid bound to MtbC or free cob(I)alamin with dimethylamine, indicating MtbB1 carries an active site for dimethylamine demethylation and corrinoid methylation

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