2.1.1.106: tryptophan 2-C-methyltransferase

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For detailed information about tryptophan 2-C-methyltransferase, go to the full flat file.

Reaction

Synonyms

S-adenosylmethionine:tryptophan 2-methyltransferase, thiostrepton A tryptophan methyltransferase, thiostrepton tryptophan methyltransferase, tryptophan 2-methyltransferase, TsrM, TsrT

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.106 tryptophan 2-C-methyltransferase

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Results	in table
27	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
4	Cofactor
1	General Information
2	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
1	Localization
2	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
5	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.1.1.106 - tryptophan 2-C-methyltransferase

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S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase

The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis. It is a radical SAM enzyme that contains a [4Fe-4S] center and a cobalamin cofactor. The enzyme first transfers the methyl group from SAM to the bound cobalamin, followed by transfer from methylcobalamin to L-tryptophan, resulting in retention of the original methyl group configuration. The second transfer is likely to involve a CH3 radical species formed from methylcobalamin by the concerted action of a partially ligated radical SAM [4Fe-4S]2+/1+ center.