2.1.1.106: tryptophan 2-C-methyltransferase

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For detailed information about tryptophan 2-C-methyltransferase, go to the full flat file.

Reaction

Synonyms

S-adenosylmethionine:tryptophan 2-methyltransferase, thiostrepton A tryptophan methyltransferase, thiostrepton tryptophan methyltransferase, tryptophan 2-methyltransferase, TsrM, TsrT

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.106 tryptophan 2-C-methyltransferase

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Results	in table
27	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
4	Cofactor
1	General Information
2	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
1	Localization
2	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
5	Specific Activity [micromol/min/mg]
1	Storage Stability
12	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Reference

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Reference on EC 2.1.1.106 - tryptophan 2-C-methyltransferase

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485082

Frenzel, T.; Zhou, P.; Floss, H.G.

Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosyl-methionine:tryptophan 2-methyltransferase

Arch. Biochem. Biophys.

278

35-40

1990

Streptomyces laurentii

2321967

734748

Pierre, S.; Guillot, A.; Benjdia, A.; Sandstr�m, C.; Langella, P.; Berteau, O.

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes

Nat. Chem. Biol.

957-959

2012

Streptomyces laurentii (C0JRZ9)

23064318

757245

Blaszczyk, A.; Knox, H.; Booker, S.

Understanding the role of electron donors in the reaction catalyzed by Tsrm, a cobalamin-dependent radical S-adenosylmethionine methylase

J. Biol. Inorg. Chem.

831-839

2019

Streptomyces laurentii (C0JRZ9)

31350635

757761

Benjdia, A.; Pierre, S.; Gherasim, C.; Guillot, A.; Carmona, M.; Amara, P.; Banerjee, R.; Berteau, O.

The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

Nat. Commun.

8377

2015

Streptomyces laurentii (C0JRZ9)

26456915