2.1.1.106: tryptophan 2-C-methyltransferase
This is an abbreviated version!
For detailed information about tryptophan 2-C-methyltransferase, go to the full flat file.
Reaction
Synonyms
S-adenosylmethionine:tryptophan 2-methyltransferase, thiostrepton A tryptophan methyltransferase, thiostrepton tryptophan methyltransferase, tryptophan 2-methyltransferase, TsrM, TsrT
ECTree
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General Information
General Information on EC 2.1.1.106 - tryptophan 2-C-methyltransferase
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physiological function
TsrM can catalyze multiple turnovers in the absence of any reducing agent, but only when it is pre-loaded with methylcobalamin. When hydroxocobalamin or cob(II)alamin is bound to TsrM, a reductant is required to convert it to cob(I)alamin, which can acquire a methyl group directly from S-adenosylmethionine. TrsM is most active when flavodoxin/flavodoxin reductase/NADPH is included in the reaction