1.14.99.14: progesterone 11alpha-monooxygenase

This is an abbreviated version!
For detailed information about progesterone 11alpha-monooxygenase, go to the full flat file.

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Synonyms

CYP106A2, CYP5311B1, progesterone 11alpha-hydroxylase, steroid 11alpha-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.99 Miscellaneous

                1.14.99.14 progesterone 11alpha-monooxygenase

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Results	in table
14	Activating Compound
2	AA Sequence
4	Application
1	CAS Registry Number
3	Cloned(Commentary)
11	Cofactor
2	Expression
2	General Stability
11	Inhibitors
15	kcat/KM [mM/s]
14	KM Value [mM]
18	Localization
1	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
49	Organism
1	Pathway
1	pH Optimum
17	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reaction Type
37	Reference
15	Source Tissue
2	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
4	Subunits
6	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
15	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.14.99.14 - progesterone 11alpha-monooxygenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

11-deoxycorticosterone + AH2 + O2

? + A + H2O

2 entries

11-deoxycortisol + AH2 + O2

? + A + H2O

2 entries

11alpha-hydroxyprogesterone + NADPH + O2

6beta,11alpha-dihydroxyprogesterone

2 entries

16,17alpha-epoxyprogesterone + AH2 + O2

11alpha-hydroxy-16,17alpha-epoxyprogesterone + A + H2O

2 entries

16alpha,17-epoxyprogesterone + AH2 + O2

11alpha-hydroxy-16alpha,17-epoxyprogesterone + A + H2O

2 entries

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

10 entries

19-nortestosterone + NADPH + O2

11alpha-hydroxy-19-nortestosterone + NADP+ + H2O

2 entries

progesterone + AH2 + O2

11alpha-hydroxyprogesterone + A + H2O

3 entries

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

25 entries

testosterone + AH2 + O2

11alpha-hydroxytestosterone + A + H2O

2 entries

additional information

?

-

10 entries

11-deoxycorticosterone + AH2 + O2

? + A + H2O

Rhizopus arrhizus

-

-

715693

-

-

?

11-deoxycorticosterone + AH2 + O2

? + A + H2O

Rhizopus arrhizus RA 99-880

-

-

715693

-

-

?

11-deoxycortisol + AH2 + O2

? + A + H2O

Rhizopus arrhizus

-

-

715693

-

-

?

11-deoxycortisol + AH2 + O2

? + A + H2O

Rhizopus arrhizus RA 99-880

-

-

715693

-

-

?

11alpha-hydroxyprogesterone + NADPH + O2

6beta,11alpha-dihydroxyprogesterone

Aspergillus ochraceus

-

-

438354

-

438354

?

11alpha-hydroxyprogesterone + NADPH + O2

6beta,11alpha-dihydroxyprogesterone

Aspergillus ochraceus NRRL 405

-

-

438354

-

438354

?

16,17alpha-epoxyprogesterone + AH2 + O2

11alpha-hydroxy-16,17alpha-epoxyprogesterone + A + H2O

Absidia caerulea

A0A173GQ95

-

745647

-

-

?

16,17alpha-epoxyprogesterone + AH2 + O2

11alpha-hydroxy-16,17alpha-epoxyprogesterone + A + H2O

Absidia caerulea AS3.65

A0A173GQ95

-

745647

-

-

?

16alpha,17-epoxyprogesterone + AH2 + O2

11alpha-hydroxy-16alpha,17-epoxyprogesterone + A + H2O

Rhizopus arrhizus

-

-

744807

-

-

?

16alpha,17-epoxyprogesterone + AH2 + O2

11alpha-hydroxy-16alpha,17-epoxyprogesterone + A + H2O

Rhizopus arrhizus CICC 40467

-

-

744807

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Aspergillus ochraceus

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Aspergillus ochraceus CICC41473

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Beauveria bassiana

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Beauveria bassiana ACCC30728

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Cunninghamella elegans

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Cunninghamella elegans CICC40250

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Metarhizium anisopliae

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Metarhizium anisopliae ACCC30194

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Rhizopus stolonifer

-

-

746508

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

Rhizopus stolonifer CGMCC33900

-

-

746508

-

-

?

19-nortestosterone + NADPH + O2

11alpha-hydroxy-19-nortestosterone + NADP+ + H2O

Aspergillus ochraceus

-

-

438354

-

-

?

19-nortestosterone + NADPH + O2

11alpha-hydroxy-19-nortestosterone + NADP+ + H2O

Aspergillus ochraceus NRRL 405

-

-

438354

-

-

?

progesterone + AH2 + O2

11alpha-hydroxyprogesterone + A + H2O

Priestia megaterium

Q06069

-

727305

-

-

?

progesterone + AH2 + O2

11alpha-hydroxyprogesterone + A + H2O

Rhizopus arrhizus

-

-

715693

-

-

?

progesterone + AH2 + O2

11alpha-hydroxyprogesterone + A + H2O

Rhizopus arrhizus RA 99-880

-

-

715693

-

-

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus

-

-

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus

-

-

438354

-

438354

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus

-

-

438356

-

438356

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus

-

-

438362

-

438362

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus

-

activity dependent upon NADPH and O2

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus G8

-

-

438362

-

438362

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus NRRL 405

-

-

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus NRRL 405

-

activity dependent upon NADPH and O2

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus NRRL 405

-

-

438354

-

438354

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus TS

-

-

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus TS

-

activity dependent upon NADPH and O2

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus TS

-

-

438356

-

438356

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Aspergillus ochraceus TS

-

-

438362

-

438362

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Priestia megaterium

-

-

438354

-

438354

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus arrhizus

-

-

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

288562

-

288562

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

438355

-

438355

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

438358

-

438358

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

438359

-

438359

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

438360

-

438360

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

438361

-

438361

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

438362

-

438362

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

-

438363

-

438363

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

multicomponent monooxygenase system

438363

-

438363

?

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

Rhizopus stolonifer

-

necessary step in the synthesis of cortico-steroid hormones

438360

-

438360

?

testosterone + AH2 + O2

11alpha-hydroxytestosterone + A + H2O

Rhizopus arrhizus

-

-

715693

-

-

?

testosterone + AH2 + O2

11alpha-hydroxytestosterone + A + H2O

Rhizopus arrhizus RA 99-880

-

-

715693

-

-

?

additional information

?

-

Absidia caerulea

A0A173GQ95

the enzyme shows low activity on progesterone and no activities on testosterone and 11-deoxycortisol

745647

-

-

?

additional information

?

-

Absidia caerulea

-

the enzyme shows low activity on progesterone and no activities on testosterone and 11-deoxycortisol

745647

-

-

?

additional information

?

-

Absidia caerulea AS3.65

A0A173GQ95

the enzyme shows low activity on progesterone and no activities on testosterone and 11-deoxycortisol

745647

-

-

?

additional information

?

-

Aspergillus ochraceus

-

11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity

438354

-

-

?

additional information

?

-

Aspergillus ochraceus NRRL 405

-

11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity

438354

-

-

?

additional information

?

-

Priestia megaterium

Q06069

the enzyme is capable of converting useful pharmaceutical targets such as 3-oxo-DELTA4-steroids (e.g., testosterone, 11-deoxycorticosterone, androstenedione, and progesterone) mainly into their 15beta-hydroxy homologues. In addition, the enzyme hydroxylates progesterone to a minor extent at the 11alpha-, 9alpha-, and 6beta-positions

727305

-

-

?

additional information

?

-

Priestia megaterium

Q06069

CYP106A2-catalyzed hydroxylations of progesterone at the 15beta-, 11alpha-, 9alpha-, and 6beta-positions

727305

-

-

?

additional information

?

-

Rhizopus arrhizus

-

hydroxylations take place predominantly at 11alpha and 6beta positions of the steroid ring system

715693

-

-

?

additional information

?

-

Rhizopus arrhizus RA 99-880

-

hydroxylations take place predominantly at 11alpha and 6beta positions of the steroid ring system

715693

-

-

?

additional information

?

-

Rhizopus stolonifer

-

multi-enzyme complex contains cytochrome P450 and NADPH cytochrome c reductase

438360

-

-

?