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Literature summary for 1.14.99.14 extracted from

  • Shibahara, M.; Moody, J.A.; Smith, L.L.
    Microbial hydroxylations. V. 11alpha-hydroxylation of progesterone by cell-free preparations of Aspergillus ochraceus (1979), Biochim. Biophys. Acta, 202, 172-179.
    View publication on PubMed
Search for more literature for 1.14.99.14

Activating Compound

Activating Compound Comment Organism Structure
11alpha-hydroxyprogesterone induced by Aspergillus ochraceus
nortestosterone induced by Aspergillus ochraceus
progesterone best inducer Aspergillus ochraceus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
progesterone + NADPH + O2 Priestia megaterium
-
 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
progesterone + NADPH + O2 Aspergillus ochraceus
-
 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
progesterone + NADPH + O2 Aspergillus ochraceus NRRL 405
-
 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus ochraceus
-
-
-
Aspergillus ochraceus NRRL 405
-
-
-
Priestia megaterium
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
 Aspergillus ochraceus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11alpha-hydroxyprogesterone + NADPH + O2
-
 Aspergillus ochraceus 6beta,11alpha-dihydroxyprogesterone
-
 ?
11alpha-hydroxyprogesterone + NADPH + O2
-
 Aspergillus ochraceus NRRL 405 6beta,11alpha-dihydroxyprogesterone
-
 ?
19-nortestosterone + NADPH + O2
-
 Aspergillus ochraceus 11alpha-hydroxy-19-nortestosterone + NADP+ + H2O
-
 ?
19-nortestosterone + NADPH + O2
-
 Aspergillus ochraceus NRRL 405 11alpha-hydroxy-19-nortestosterone + NADP+ + H2O
-
 ?
additional information 11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity Aspergillus ochraceus ?
-
 ?
additional information 11alpha-hydroxylase induced by progesterone or 19-nortestosterone is free from associated 6beta-hydroxylase or 17beta-hydroxysteroid dehydrogenase activity, but induction with 11alpha-hydroxyprogesterone yields an enzyme with both 6beta- and 11alpha-hydroxylase activity Aspergillus ochraceus NRRL 405 ?
-
 ?
progesterone + NADPH + O2
-
 Priestia megaterium 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
progesterone + NADPH + O2
-
 Aspergillus ochraceus 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?
progesterone + NADPH + O2
-
 Aspergillus ochraceus NRRL 405 11alpha-hydroxyprogesterone + NADP+ + H2O
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
30
-
 loses potency at higher temperatures Aspergillus ochraceus