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1.14.99.1: prostaglandin-endoperoxide synthase

This is an abbreviated version!
For detailed information about prostaglandin-endoperoxide synthase, go to the full flat file.

Word Map on EC 1.14.99.1

Reaction

arachidonate
+
reduced acceptor
 + 2 O2 =
prostaglandin H2
 +
acceptor
 +
H2O

Synonyms

(PG)H synthase, COX, COX-1, COX-2, COX1, Cox2, cyclooxygenase, cyclooxygenase 1, cyclooxygenase 2, cyclooxygenase-1, cyclooxygenase-1b, cyclooxygenase-2, cycloxigenase-2, fatty acid cyclooxygenase, hPGHS-1, hPGHS-2, oPGHS-1, PG G/H synthase 2, PG H synthase, PG synthetase, PG-endoperoxide synthase 2, PG-endoperoxide synthetase, PGH-synthase, PGHS, PGHS isoform-1, PGHS-1, PGHS-2, PHS, PHS-1, PHS-2, prostagladin-H synthase, prostaglandin endoperoxide H synthase, prostaglandin endoperoxide H synthase 1, prostaglandin endoperoxide H synthase 2, prostaglandin endoperoxide H synthase-1, prostaglandin endoperoxide H2 synthase-2, prostaglandin endoperoxide synthase, prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase-1, prostaglandin endoperoxide synthase-2, prostaglandin endoperoxide synthetase, prostaglandin G/H synthase, prostaglandin G/H synthase-2, prostaglandin H synthase, prostaglandin H synthase-1, prostaglandin H synthase-2, prostaglandin H2 synthase, prostaglandin H2 synthase-1, prostaglandin synthase, prostaglandin synthase-2, prostaglandin synthetase, prostaglandin-endoperoxide synthase, prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 2, prostaglandin-H-synthase, prostaglandin-H-synthase 1, prostaglandin-H-synthase 2, PTGS 2, PTGS-1, PTGS-2, PTGS1, PTGS2, putative cyclooxygenase-3, synthase, prostaglandin, tPGHS-1, tPGHS-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.1 prostaglandin-endoperoxide synthase

KM Value

KM Value on EC 1.14.99.1 - prostaglandin-endoperoxide synthase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0368
(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid
pH 8.0, 25°C, COX-2 mutant N580A
0.00945
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid
pH 8.0, 25°C, COX-2 mutant N580A
0.0031 - 0.082
alpha-linolenic acid
0.0009 - 0.015
arachidonate
0.001 - 0.16
arachidonic acid
0.0052 - 0.0091
cis-11,14-eicosadienoic acid
0.0011 - 0.07
cis-4,7,10,13,16,19-docosahexaenoic acid
0.0012 - 0.039
cis-5,8,11,14,17-eicosapentaenoic acid
0.0017 - 0.013
cis-5,8,11,14-eicosatetraenoic acid
0.0027 - 0.061
cis-7,10,13,16-docosatetraenoic acid
0.002 - 0.036
cis-8,11,14-eicosatrienoic acid
0.0048 - 0.162
gamma-linolenic acid
0.08 - 0.29
guaiacol
1.3 - 5.5
H2O2
0.0055 - 0.0068
linoleic acid
0.0083 - 0.0854
N,N,N',N'-tetramethyl-p-phenylenediamine
0.005 - 0.011
O2
0.02 - 0.437
trans-5-phenyl-4-pentenyl-1-hydroperoxide
additional information
additional information
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