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Literature summary for 1.14.99.1 extracted from
- Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms (2009), Prostaglandins Leukot. Essent. Fatty Acids, 80, 239-245.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Ovis aries |
| expressed in colon carcinoma cells COLO320DM | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | guava leaf extract inhibits the catalytic activity of the PGHS-1 isoform using linoleic acid as substrate (IC50 value of 0.055 mg of dry leaf extract); guava leaf extract inhibits the catalytic activity of the PGHS-2 isoform using linoleic acid as substrate (IC50 value of 0.56 mg of dry leaf extract); isozyme PGHS-1 is hardly inhibited by ellagic acid; isozyme PGHS-2 is hardly inhibited by ellagic acid | Homo sapiens | |
| additional information | guava leaf extract inhibits the catalytic activity of the PGHS-1 and PGHS-2 isoforms using linoleic acid as substrate; guava leaf extract inhibits the catalytic activity of the PGHS-1 and PGHS-2 isoforms using linoleic acid as substrate; isozyme PGHS-1 is hardly inhibited by ellagic acid; isozyme PGHS-2 is hardly inhibited by ellagic acid | Ovis aries | |
| quercetin | - |
Homo sapiens |  |
| quercetin | - |
Ovis aries | |
| quercetin 3-O-glucoside | - |
Homo sapiens | |
| quercetin 3-O-glucoside | - |
Ovis aries | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0055 | - |
linoleic acid | isozyme PGHS-1, in 100 mM Tris-HCl buffer (pH 7.4), at 24°C | Homo sapiens | |
| 0.0068 | - |
linoleic acid | isozyme PGHS-2, in 100 mM Tris-HCl buffer (pH 7.4), at 24°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P23219 | - |
- |
| Homo sapiens | P35354 | - |
- |
| Ovis aries | P05979 | - |
- |
| Ovis aries | P79208 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonic acid + AH2 + 2 O2 | - |
Homo sapiens | prostaglandin E2 + A + H2O | - |
? | |
| arachidonic acid + AH2 + 2 O2 | - |
Ovis aries | prostaglandin E2 + A + H2O | - |
? | |
| linoleic acid + AH2 + O2 | - |
Homo sapiens | 9-hydroxyoctadecadienoic acid + 13-hydroxyoctadecadienoic acid + ? | - |
? | |
| linoleic acid + AH2 + O2 | - |
Ovis aries | 9-hydroxyoctadecadienoic acid + 13-hydroxyoctadecadienoic acid + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGHS-1 | isoform | Homo sapiens |
| PGHS-1 | isoform | Ovis aries |
| PGHS-2 | isoform | Homo sapiens |
| PGHS-2 | isoform | Ovis aries |
| prostaglandin endoperoxide H synthase | - |
Homo sapiens |
| prostaglandin endoperoxide H synthase | - |
Ovis aries |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
isozyme PGHS-1, in 100 mM Tris-HCl buffer (pH 7.4), at 24°C | Homo sapiens | quercetin | |
| 0.086 | - |
isozyme PGHS-2, in 100 mM Tris-HCl buffer (pH 7.4), at 24°C | Homo sapiens | quercetin | |
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Release 2023.1 (January 2023)
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