Literature summary for 1.14.99.1 extracted from

Forghani, F.; Ouellet, M.; Keen, S.; Percival, M.D.; Tagari, P.
Analysis of prostaglandin G/H synthase-2 inhibition using peroxidase-induced luminol luminescence (1998), Anal. Biochem., 264, 216-221.

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Application

Application	Comment	Organism
medicine	use of peroxidase activity for luminol assay of inflammation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
5-bromo-2-[4-fluorophenyl]-3-[4-methylsulfonylphenyl]-thiophene	50% inhibition at 8.7 nM	Homo sapiens
diclofenac	50% inhibition at 9.4 nM	Homo sapiens
flosulide	selective for isozyme 2, 50% inhibition at 130 nM	Homo sapiens
Flufenamic acid	50% inhibition at 0.02 mM	Homo sapiens
Ibuprofen	50% inhibition at 0.253 mM	Homo sapiens
indomethacin	50% inhibition at 100 nM	Homo sapiens
N-[2-cyclohexyloxy-4-nitrophenyl]methanesulfonamide	50% inhibition at 81 nM	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.006	-	arachidonic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme, product of COX-2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + electron donor + O2	-	Homo sapiens	prostaglandin H2 + oxidized electron donor + H2O	-	?

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Release 2023.1 (January 2023)