Literature summary for 1.14.99.1 extracted from

Kargman, S.; Wong, E.; Greig, G.M.; Falgueyret, J.P.; Cromlish, W.; Ethier, D.; Yergey, J.A.; Riendeau, D.; Evans, J.F.; Kennedy, B.; Tagari, P.; Francis, D.A.; O'Neill, G.P.
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells (1996), Biochem. Pharmacol., 52, 1113-1125.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-bromo-2-[4-fluorophenyl]-3-[4-methylsulfonylphenyl]-thiophene	DuP-697, selective for isozyme 2	Homo sapiens
Ibuprofen	reversible	Homo sapiens
indomethacin	reversible and time-dependent inhibition	Homo sapiens
additional information	mechanism of selective inhibition	Homo sapiens
N-[2-cyclohexyloxy-4-nitrophenyl]methanesulfonamide	NS-398, selective for isozyme 2	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.001	-	arachidonic acid	isozyme 1 and 2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme, product of COX-2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + electron donor + O2	-	Homo sapiens	prostaglandin H2 + oxidized electron donor + H2O	-	?

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Release 2023.1 (January 2023)