1.14.11.1: gamma-butyrobetaine dioxygenase

This is an abbreviated version!
For detailed information about gamma-butyrobetaine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.1

1.14.11.1

cardioprotective

carnitine-dependent

3-2,2,2-trimethylhydrazinium

mildronate

trimethyllysine

mid1

alpha4

medicine

d-carnitine

dihydrate

drug development

molecular biology

Reaction

Synonyms

4-trimethylaminobutyric acid dioxygenase, alpha-butyrobetaine hydroxylase, BBD, BBH, BBOX, BBOX1, Bu hydroxylase, butyrobetaine hydroxylase, gamma butyrobetaine hydroxylase, gamma-BBD, gamma-BBH, gamma-buryrobetaine dioxygenase, gamma-butyrobetaine dioxygenase, gamma-butyrobetaine hydroxylase, gamma-butyrobetaine hydroxylase 1, GBB hydroxylase, GBBH, hBBOX, oxygenase, gamma-butyrobetaine di-, psBBOX

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.1 gamma-butyrobetaine dioxygenase

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Results	in table
27	Activating Compound
1493	AA Sequence
7	Application
1	CAS Registry Number
8	Cloned(Commentary)
15	Cofactor
4	Crystallization (Commentary)
46	Disease/ Diagnostics
4	Expression
26	General Information
4	General Stability
80	IC50 Value
157	Inhibitors
7	Ki Value [mM]
53	KM Value [mM]
15	Localization
25	Metals/Ions
13	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
88	Organism
2	Oxidation Stability
6	Pathway
17	PDB ID
9	pH Optimum
2	pH Range
14	Purification (Commentary)
4	Reaction
4	Reaction Type
55	Reference
61	Source Tissue
20	Specific Activity [micromol/min/mg]
5	Storage Stability
91	Substrates and Products (Substrate)
18	Subunits
51	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.11.1 - gamma-butyrobetaine dioxygenase

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2-amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine

ascorbate

catalase

Cs+

increase of activity

GSH/GSH-peroxidase

increase of activity, more efficient in assay and during preincubation than catalase, protects the enzyme from increasing phosphate concentrations

isoascorbate

increase of activity

K+

efficient coupling of decarboxylation and hydroxylation, stimulation

L-ascorbate

required

L-histidine

Microsomal preparation

Rattus norvegicus

increase of activity

439297

NADPH

Rattus norvegicus

NADPH-regenerating system, increase of activity, no absolute requirement

NH4+

increase of activity

nicotinamide

increase of activity

Rb+

increase of activity

additional information

Pseudomonas sp.

various proteins such as lactoperoxidase, horseradish peroxidase, hemoglobin, myoglobin, cytochrome c, bovine serum albumin activate

439288