EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.71 | C338A |
the mutation in isoform ECE-1b creates a new E2F-2 transcription factor binding site and enhances expression of this intracellular isoform |
734021 |
| 3.4.24.71 | C428S |
mutant of monomeric form |
699564 |
| 3.4.24.71 | K198N |
naturally occuring polymorphism, the mutant shows impaired function |
683965 |
| 3.4.24.71 | more |
construction of transgenic mice overexpressing human amyloid-beta peptide and protein kinase C epsilon, overview, increased ECE activity in PKCepsilon-transfected EA.hy926 cells |
684002 |
| 3.4.24.71 | more |
dual neprilysin/ECE knock-out mice show additive effects on amyloid-beta peptide accumulation, overview |
683628 |
| 3.4.24.71 | more |
ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, overview |
683696 |
| 3.4.24.71 | more |
ECE-1 overexpression attenuates ERK2 activation |
709039 |
| 3.4.24.71 | more |
increased ECE activity in PKCepsilon-transfected EA.hy926 cells |
684002 |
| 3.4.24.71 | more |
overexpression of ECE-1a or 1b in CHO cells results in a 75-90% reduction in Abeta1-40 and a 45-60% reduction in Abeta1-42, completely abolished by treatment with phosphoramidon |
710094 |
| 3.4.24.71 | more |
the C338A polymorphism, that is located in the ECE-1 gene promoter, occurs in gene ECE-1b in carotid atherosclerosis, genotyping of a Chinese population, carotid atherosclerosis patients and healthy subjects, overview |
709856 |
